Introduction We aimed to compare the predictive accuracy of surrogate indices namely the lipid accumulation product (LAP) index, homeostatic model of assessment of insulin resistance (HOMA-IR), fasting glucose-insulin ratio (FG-IR) and the quantitative-insulin sensitivity check index (QUICKI), against the M value of hyperinsulinemic-euglycemic clamp (HEC), and to determine a cut-off value for the LAP index to predict risk of insulin resistance in non-obese (body mass index <21 kg/m2), normoglycemic, Asian Indian males from Southern India. Research design and methods Data of HEC studies performed in 108 non-obese, normoglycemic, Asian Indian males was obtained retrospectively and the M value (a measure of whole-body insulin sensitivity) was calculated. The M value is the rate of whole-body glucose metabolism at the hyperinsulinemic plateau (a measure of insulin sensitivity) and is calculated between 60 and 120 min after the start of the insulin infusion in the HEC procedure. The LAP index, the HOMA-IR, FG-IR and QUICKI were calculated. Spearman’s correlation and logistic regression analysis were performed. Cut-off value for the LAP index was obtained using receiver operating characteristics with area under curve (AUC) analysis at 95% CI. P value <0.05 was considered to be statistically significant. Results Significant negative correlation was observed for the M value with LAP index (r=−0.39, p<0.001) while significant positive correlation was noted with FG-IR (r=0.25; p<0.01) and QUICKI (r=0.22; p<0.01). The LAP index cut-off value ≥33.4 showed 75% sensitivity and 75% specificity with AUC (0.72) to predict risk of insulin resistance in this cohort. Conclusion The LAP index showed higher predictive accuracy for the risk of insulin resistance as compared with HOMA-IR, QUICKI and FG-IR in non-obese, normoglycemic Asian Indian males from Southern India. All data relevant to the study are included in the article. All data relevant to the study are included in the article as tables, text and figures.

中文翻译：

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脂质积累产物 (LAP) 作为预测来自印度南部的年轻、非肥胖亚洲印度男性胰岛素抵抗风险的潜在指标：来自高胰岛素-正常血糖钳夹研究的观察结果

介绍我们旨在比较替代指标的预测准确性，即脂质积累产物 (LAP) 指数、胰岛素抵抗评估的稳态模型 (HOMA-IR)、空腹葡萄糖 - 胰岛素比 (FG-IR) 和定量胰岛素敏感性检查指数 (QUICKI)，对照高胰岛素正常血糖钳夹 (HEC) 的 M 值，并确定 LAP 指数的临界值，以预测非肥胖（体重指数 <21 kg/m2）胰岛素抵抗的风险)，来自南印度的正常血糖的亚裔印度男性。研究设计和方法 回顾性获得了在 108 名非肥胖、血糖正常的亚洲印度男性中进行的 HEC 研究数据，并计算了 M 值（全身胰岛素敏感性的度量）。M 值是高胰岛素血症平台期的全身葡萄糖代谢率（胰岛素敏感性的衡量标准），在 HEC 程序中胰岛素输注开始后 60 至 120 分钟之间计算。计算 LAP 指数、HOMA-IR、FG-IR 和 QUICKI。进行斯皮尔曼相关性和逻辑回归分析。LAP 指数的临界值是使用接受者操作特征与曲线下面积 (AUC) 分析在 95% CI 下获得的。P值<0.05被认为具有统计学意义。结果 M 值与 LAP 指数显着负相关（r=-0.39，p<0.001），而与 FG-IR（r=0.25；p<0.01）和 QUICKI（r=0.22；p）显着正相关<0.01)。LAP 指数临界值≥33。4 显示了 75% 的敏感性和 75% 的特异性，AUC (0.72) 在该队列中预测胰岛素抵抗的风险。结论与 HOMA-IR、QUICKI 和 FG-IR 相比，LAP 指数对来自印度南部的非肥胖、血糖正常的亚洲印度男性胰岛素抵抗风险的预测准确性更高。与研究相关的所有数据都包含在文章中。与研究相关的所有数据都以表格、文本和图形的形式包含在文章中。