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Varying international practices regarding the evaluation of febrile young infants
Archives of Disease in Childhood ( IF 4.3 ) Pub Date : 2021-11-01 , DOI: 10.1136/archdischild-2021-323001
Etimbuk Umana 1 , Thomas Waterfield 2
Affiliation  

Identifying children with serious bacterial infection (SBI) can be challenging. To aid clinicians in the UK and Ireland, the National Institute for Health and Care Excellence (NICE) provides guidance on those children at greatest risk via NICE guideline (NG51) Sepsis: recognition, diagnosis and early management. One of those ‘high risk’ groups are infants under 3 months of age presenting with a fever or history of fever over 38°C. For this high-risk group, NICE NG51 recommends extensive investigation and administration of broad-spectrum antibiotics to all within the hour.1 Internationally, however, approaches differ. In the USA and Europe, validated clinical decision tools have been developed.2 3 These tools allow for a tailored approach that reduces the need for painful interventions such as lumbar puncture, improves antimicrobial stewardship and reduces the need for hospital admission.2 3 Although approaches to assessment and management vary internationally, there are some areas where we do agree. The rates of serious bacterial infections are similar in the UK, Europe and the USA with between 10% and 20% of febrile young infants having a serious bacterial infection,2–4 the majority of which (9%–17%) will be urinary tract infections and (1%–3%) will be invasive bacterial infections such as meningitis and bacterial sepsis.2–4 We all agree that younger infants under 28 days of age are at higher risk for serious bacterial infections and finally we all agree that no pattern of clinical features or exam findings can be used to …

中文翻译:

关于评估发热小婴儿的不同国际惯例

识别患有严重细菌感染 (SBI) 的儿童可能具有挑战性。为了帮助英国和爱尔兰的临床医生,国家健康与护理卓越研究所 (NICE) 通过 NICE 指南 (NG51) 脓毒症:识别、诊断和早期管理为那些面临最大风险的儿童提供指导。这些“高风险”群体之一是出现发烧或发烧超过 38°C 的 3 个月以下婴儿。对于这一高危人群,NICE NG51 建议在 1 小时内对所有人进行广泛调查和广谱抗生素给药。1 然而,国际上的方法有所不同。在美国和欧洲,已经开发出经过验证的临床决策工具。 2 3 这些工具允许采用量身定制的方法,减少对腰椎穿刺、改善抗菌药物管理并减少住院需求。2 3 尽管评估和管理方法在国际上有所不同,但在某些方面我们确实同意。英国、欧洲和美国的严重细菌感染率相似,有 10% 至 20% 的发热小婴儿患有严重细菌感染,2–4 其中大部分 (9%–17%) 是泌尿系统感染道感染和(1%–3%)将是侵袭性细菌感染,例如脑膜炎和细菌性败血症。2–4 我们都同意,28 天以下的小婴儿发生严重细菌感染的风险更高,最后我们都同意没有任何临床特征或检查结果模式可用于…… 有些领域我们确实同意。英国、欧洲和美国的严重细菌感染率相似,有 10% 至 20% 的发热小婴儿患有严重细菌感染,2–4 其中大部分 (9%–17%) 是泌尿系统感染道感染和(1%–3%)将是侵袭性细菌感染,例如脑膜炎和细菌性败血症。2–4 我们都同意,28 天以下的小婴儿发生严重细菌感染的风险更高,最后我们都同意没有任何临床特征或检查结果模式可用于…… 有些领域我们确实同意。英国、欧洲和美国的严重细菌感染率相似,有 10% 至 20% 的发热小婴儿患有严重细菌感染,2–4 其中大部分 (9%–17%) 是泌尿系统感染道感染和(1%–3%)将是侵袭性细菌感染,例如脑膜炎和细菌性败血症。2–4 我们都同意,28 天以下的小婴儿发生严重细菌感染的风险更高,最后我们都同意没有任何临床特征或检查结果模式可用于……
更新日期:2021-10-20
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