There are certain disadvantages in treating bacterial infections through conventional methods. For this reason, the current study does focus on combating bacterial wound infections by photothermal therapy assisted by gold nanorod-peptide conjugates (GNR-peptide conjugates). Two peptides, the cationic antimicrobial peptide LL-37 and neuropeptide ANGIOPEP-2 both with specificity for targeted bacterial binding, were conjugated with GNR surface through electrostatic interactions. The GNR-peptide conjugates showed good biocompatibility, sufficient stability, enhanced targeting, potential photothermal killing of bacteria, and possible acceleration of wound healing. The photo-biomodulation properties of NIR improved the wound closure rates through enhanced cell migration. The multifunctional LL37-conjugated GNRs significantly enhanced photothermal therapeutic outcomes based on bacterial targeting with promising wound healing properties.

通过常规方法治疗细菌感染存在一定的缺点。出于这个原因，目前的研究确实侧重于通过金纳米棒-肽缀合物（GNR-肽缀合物）辅助的光热疗法来对抗细菌性伤口感染。两种肽，阳离子抗菌肽 LL-37 和神经肽 ANGIOPEP-2，均具有靶向细菌结合的特异性，通过静电相互作用与 GNR 表面缀合。GNR-肽缀合物显示出良好的生物相容性、足够的稳定性、增强的靶向性、潜在的光热杀灭细菌以及可能加速伤口愈合。NIR 的光生物调节特性通过增强细胞迁移提高了伤口闭合率。