The inflammation of adipose tissue is one of the most common secondary pathological changes in atherosclerosis, which in turn influences the process of atherosclerosis. Natriuretic peptides have been revealed important effect in regulating adipose metabolism. However, the relationship between natriuretic peptide receptor C and inflammation of adipose tissue in atherosclerosis remains unknown. This study aims to explore the effect natriuretic peptide receptor C exerts on the regulation of the adipose inflammation in atherosclerotic mice induced by western-type diet and its overlying mechanisms. To clarify the importance of NPRC of adipose inflammation in atherosclerotic mice, NPRC expression was measured in mice fed with chow diet and western-type diet for 12 weeks and we found a considerable increase in adipose tissue of atherosclerotic mice. Global NPRC knockout in mice was bred onto ApoE^−/− mice to generate NPRC^−/−ApoE^−/− mice, which displayed remarked increase in browning of white adipose tissue and lipolysis of adipose tissue and decrease in adipose inflammation manifested by decreased macrophage invasion to form less CLS (crown-like structure), reduced oxidative stress and alleviated expression of TNFα, IL-6, IL-1β and MCP1, but increased expression of adiponectin in adipose tissue. Moreover, our study showed that white adipose tissue browning in NPRC^−/−ApoE^−/− atherosclerotic mice was associated with decreased inflammatory response through cAMP/PKA signalling activation. These results identify NPRC as a novel regulator for adipose inflammation in atherosclerotic mice by modulating white adipose tissue browning.

中文翻译：

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利钠肽受体 C 的缺失可减轻高胆固醇血症载脂蛋白 E 基因敲除小鼠的脂肪组织炎症

脂肪组织的炎症是动脉粥样硬化最常见的继发性病理变化之一，进而影响动脉粥样硬化的进程。利钠肽已被揭示在调节脂肪代谢中具有重要作用。然而，利钠肽受体C与动脉粥样硬化脂肪组织炎症之间的关系仍不清楚。本研究旨在探讨利钠肽受体C对西式饮食诱导的动脉粥样硬化小鼠脂肪炎症的调节作用及其相关机制。为了阐明 NPRC 对动脉粥样硬化小鼠脂肪炎症的重要性，在喂食食物和西方饮食 12 周的小鼠中测量 NPRC 表达，我们发现动脉粥样硬化小鼠的脂肪组织显着增加。^-/-小鼠产生 NPRC ^-/- ApoE ^-/-小鼠，其白色脂肪组织褐变和脂肪组织脂肪分解显着增加，脂肪炎症减少，表现为巨噬细胞侵袭减少，形成较少的 CLS（冠状结构)，减少氧化应激并减轻 TNFα、IL-6、IL-1β 和 MCP1 的表达，但增加脂肪组织中脂联素的表达。此外，我们的研究表明，NPRC 中的白色脂肪组织褐变^-/- ApoE ^-/-动脉粥样硬化小鼠与通过 cAMP/PKA 信号激活降低的炎症反应有关。这些结果通过调节白色脂肪组织褐变将 NPRC 确定为动脉粥样硬化小鼠脂肪炎症的新调节剂。