Cotton gauzes are highly versatile medical devices for treating wounds due to their excellent absorption capacity and because they avoid contact between the wound and the environment. As materials of priority use, it is possible to take advantage of their ubiquity and use them as delivery systems for antimicrobial drugs that effectively treat skin wound infections. For this reason, this study proposes the modification of cotton gauzes through the grafting of pH-sensitive polymers, such as poly (acrylic acid) and poly (methacrylic acid), as a means of achieving drug delivery. The grafting process was carried out using gamma radiation, and the successful modification of the devices was verified with analytical techniques such as SEM, FTIR-ATR, TGA, and DSC, finding the novel properties of these modified materials. The grafted gauzes show a critical pH close to 4.7, which would allow for its application to some acidic skin wounds. In addition to the pH-buffering properties of the material, it was possible to load vancomycin onto the grafted materials as a pathway for the development of antimicrobial materials.

棉纱布是用于治疗伤口的用途广泛的医疗器械，因为它们具有出色的吸收能力，并且可以避免伤口与环境之间的接触。作为优先使用的材料，可以利用它们的普遍性，将它们用作有效治疗皮肤伤口感染的抗菌药物的递送系统。出于这个原因，本研究提出通过接枝 pH 敏感聚合物（如聚（丙烯酸）和聚（甲基丙烯酸））对棉纱布进行改性，作为实现药物递送的一种手段。使用伽马辐射进行接枝过程，并通过扫描电镜、傅里叶变换红外光谱、TGA 和 DSC 等分析技术验证了器件的成功改性，发现了这些改性材料的新特性。嫁接的纱布显示出接近 4.7 的临界 pH 值，这将允许其应用于一些酸性皮肤伤口。除了材料的 pH 缓冲特性外，还可以将万古霉素加载到接枝材料上，作为开发抗菌材料的途径。