Two new α-methoxy-γ-pyrone analogs, 2-methoxy-3-methyl-5,6-diethyl-γ-pyrone (2) and 2-methoxy-3,5-dimethyl-6-propyl-γ-pyrone (3), together with 2-methoxy-3,5-dimethyl-6-ethyl-γ-pyrone (1), firstly isolated from natural sources, were obtained from the EtOAc-solube extract of the mangrove sediment-derived actinomycete strain Streptomyces psammoticus SCSIO NS126, under the optimized fermentation conditions. Their structures were elucidated by detailed spectroscopic analysis and by comparison of their spectroscopic data with those reported in the literature. Those α-methoxy-γ-pyrones were evaluated for their acetylcholinesterase inhibitory activity; however, none of them exhibited obvious activity. Moreover, their biosynthetic relationship with piericidins was also discussed.

两种新的α-甲氧基-γ-吡喃酮类似物，2-甲氧基-3-甲基-5,6-二乙基-γ-吡喃酮 ( 2 ) 和 2-甲氧基-3,5-二甲基-6-丙基-γ-吡喃酮 ( 3 )，连同首先从天然来源分离的2-甲氧基-3,5-二甲基-6-乙基-γ-吡喃酮( 1 )，是从红树林沉积物衍生的放线菌菌株Streptomyces psammoticus的EtOAc-可溶提取物中获得的SCSIO NS126，在优化的发酵条件下。通过详细的光谱分析以及将它们的光谱数据与文献中报道的数据进行比较，阐明了它们的结构。评估了这些 α-甲氧基-γ-吡喃酮的乙酰胆碱酯酶抑制活性；然而，它们都没有表现出明显的活性。此外，还讨论了它们与 piericidins 的生物合成关系。