Selectively targeting facets of neutrophil function could benefit infectious and inflammatory diseases. Amara et al. report on a compound which blocks human neutrophil activation by activating the glycolytic enzyme phosphofructokinase, liver-type (PFKL). Altering glucose fate by modulating this key enzymatic step could dramatically alter the function and fate of phagocytes.

中文翻译：

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吞噬细胞代谢：中性粒细胞有蛋糕但不要吃

选择性靶向中性粒细胞功能的各个方面可能有益于感染性和炎症性疾病。阿马拉等人。报告了一种通过激活肝型糖酵解酶磷酸果糖激酶 (PFKL) 来阻断人类中性粒细胞活化的化合物。通过调节这一关键的酶促步骤来改变葡萄糖的命运，可以显着改变吞噬细胞的功能和命运。