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Tetrahedral framework nucleic acids facilitate neurorestoration of facial nerves by activating the NGF/PI3K/AKT pathway
Nanoscale ( IF 5.8 ) Pub Date : 2021-08-17 , DOI: 10.1039/d1nr04619e Yangxue Yao 1 , Yuting Wen 1 , Yanjing Li 1 , Jianwei Zhu 2 , Taoran Tian 1 , Qi Zhang 1 , Dexuan Xiao 1 , Yang Gao 1 , Yunfeng Lin 1, 3 , Wei Wei 4 , Xiaoxiao Cai 1
Nanoscale ( IF 5.8 ) Pub Date : 2021-08-17 , DOI: 10.1039/d1nr04619e Yangxue Yao 1 , Yuting Wen 1 , Yanjing Li 1 , Jianwei Zhu 2 , Taoran Tian 1 , Qi Zhang 1 , Dexuan Xiao 1 , Yang Gao 1 , Yunfeng Lin 1, 3 , Wei Wei 4 , Xiaoxiao Cai 1
Affiliation
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The facial nerve is a crucial nerve in the maxillofacial region and is vulnerable to damage. As a consequence of the complications during nerve restoration, existing remedies have certain limitations, thus the treatment of facial nerve injury is always a perplexing task for people. Regulation of Schwann cells is always the breakpoint of neurorestoration since Schwann cells count a great deal in injured nerve repair. In this study, we presented proof that tetrahedral framework nucleic acids (tFNAs), a kind of nucleic acid nanomaterial, were capable of regulating the neurorestorative pathway NGF/PI3 K/AKT, resulting in the activation of a series of cell behaviors related to injured nerve restoration such as proliferation and migration. In vivo experiments also proved that tFNAs enhanced the expressions of axon and myelin marker proteins, impelled histological recovery, promoted the efficient restoration of nerve conduction and muscle movement. Additionally, tFNAs possessed excellent biocompatibility and superior endocytosis ability. Thus, there is good potential for tFNAs to be applied in the therapy of facial nerve injury or even peripheral nerve injury.
中文翻译：
四面体框架核酸通过激活 NGF/PI3K/AKT 通路促进面神经的神经修复
面神经是颌面部的重要神经，容易受到损伤。由于神经修复过程中的并发症，现有的治疗方法具有一定的局限性，因此面神经损伤的治疗一直是困扰人们的难题。雪旺细胞的调节一直是神经修复的断点，因为雪旺细胞在损伤神经修复中占有重要地位。在这项研究中，我们证明了四面体框架核酸（tFNAs），一种核酸纳米材料，能够调节神经修复途径 NGF/PI3 K/AKT，导致一系列与损伤相关的细胞行为的激活。神经修复，如增殖和迁移。体内实验还证明tFNAs增强轴突和髓鞘标志蛋白的表达，促进组织学恢复，促进神经传导和肌肉运动的有效恢复。此外，tFNAs 具有优异的生物相容性和优越的内吞能力。因此，tFNAs 在面神经损伤甚至周围神经损伤的治疗中具有良好的潜力。
更新日期：2021-09-16
中文翻译：
四面体框架核酸通过激活 NGF/PI3K/AKT 通路促进面神经的神经修复
面神经是颌面部的重要神经，容易受到损伤。由于神经修复过程中的并发症，现有的治疗方法具有一定的局限性，因此面神经损伤的治疗一直是困扰人们的难题。雪旺细胞的调节一直是神经修复的断点，因为雪旺细胞在损伤神经修复中占有重要地位。在这项研究中，我们证明了四面体框架核酸（tFNAs），一种核酸纳米材料，能够调节神经修复途径 NGF/PI3 K/AKT，导致一系列与损伤相关的细胞行为的激活。神经修复，如增殖和迁移。体内实验还证明tFNAs增强轴突和髓鞘标志蛋白的表达，促进组织学恢复，促进神经传导和肌肉运动的有效恢复。此外，tFNAs 具有优异的生物相容性和优越的内吞能力。因此，tFNAs 在面神经损伤甚至周围神经损伤的治疗中具有良好的潜力。
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