NIR-II Excitation Phototheranostic Nanomedicine for Fluorescence/Photoacoustic Tumor Imaging and Targeted Photothermal-Photonic Thermodynamic Therapy,Small

当前位置： X-MOL 学术 › Small › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

NIR-II Excitation Phototheranostic Nanomedicine for Fluorescence/Photoacoustic Tumor Imaging and Targeted Photothermal-Photonic Thermodynamic Therapy
Small ( IF 13.0 ) Pub Date : 2021-09-16 , DOI: 10.1002/smll.202102527
Yeneng Dai ₁ , Honghai Zhao ₁ , Kun He ₁ , Wenyu Du ₁ , Yingjie Kong ₁ , Zhen Wang ₁ , Meixing Li ₁ , Qingming Shen ₁ , Pengfei Sun ₁ , Quli Fan ₁

Affiliation

The success of phototheranostics is hampered by some intrinsic defects, such as limited light penetration depth, heat resistance of tumor cells to photothermal therapy (PTT) induced by heat shock protein (HSP) and stress resistance against photodynamic therapy (PDT) caused by hypoxia microenvironment of tumor. Herein, a second near infrared (NIR-II) light excitation phototheranostic nanomedicine has been fabricated by integrating the semiconducting polymer, azo compound, and HSP inhibitor into a thermosensitive liposome, followed by modification with targeting aptamer, forming Lip(PTQ/GA/AIPH) for multimodal phototheranostics of triple-negative breast cancer (TNBC). The phototheranostic nanomedicine provides tumor targeting NIR-II fluorescence and photoacoustic dual-modal imaging, as well as NIR-II PTT. The released HSP inhibitor can effectively inhibit the activity of HSP for enhanced NIR-II PTT. Moreover, azo compound can be decomposed by the NIR-II photothermal activation, generating cytotoxic free radicals and realizing oxygen-irrelevant photonic thermodynamic therapy (PTDT) effects. Under the NIR-II laser irradiation, NIR-II fluorescence/photoacoustic dual-modal imaging guided enhanced NIR-II PTT and PTDT by Lip(PTQ/GA/AIPH), can achieve precise diagnosis and effective suppression of deep-seated TNBC with negligible side effects. This work develops a promising NIR-II excitation phototheranostic nanomedicine for spatiotemporally specific diagnosis and combination therapy of TNBC.

中文翻译：

用于荧光/光声肿瘤成像和靶向光热-光子热力学治疗的 NIR-II 激发光疗纳米医学

光热疗法的成功受到一些内在缺陷的阻碍，例如光穿透深度有限、肿瘤细胞对热休克蛋白 (HSP) 诱导的光热疗法 (PTT) 的耐热性以及缺氧微环境引起的光动力疗法 (PDT) 应激抵抗的肿瘤。在此，通过将半导体聚合物、偶氮化合物和 HSP 抑制剂整合到热敏脂质体中，然后用靶向适体修饰，形成 Lip(PTQ/GA/AIPH)，制备了第二种近红外 (NIR-II) 光激发光疗纳米药物。 ) 用于三阴性乳腺癌 (TNBC) 的多模式光疗。光疗纳米医学提供肿瘤靶向 NIR-II 荧光和光声双模态成像，以及 NIR-II PTT。释放的HSP抑制剂可以有效抑制HSP对增强NIR-II PTT的活性。此外，偶氮化合物可以通过 NIR-II 光热活化分解，产生细胞毒性自由基，实现与氧无关的光子热力学治疗 (PTDT) 效果。NIR-II激光照射下，NIR-II荧光/光声双模态成像引导增强NIR-II PTT和Lip（PTQ/GA/AIPH）PTDT，可实现对深部TNBC的精确诊断和有效抑制，可忽略不计副作用。这项工作开发了一种有前途的 NIR-II 激发光疗纳米医学，用于 TNBC 的时空特异性诊断和联合治疗。产生细胞毒性自由基并实现与氧无关的光子热力学治疗 (PTDT) 效果。NIR-II激光照射下，NIR-II荧光/光声双模态成像引导增强NIR-II PTT和Lip（PTQ/GA/AIPH）PTDT，可实现对深部TNBC的精确诊断和有效抑制，可忽略不计副作用。这项工作开发了一种有前途的 NIR-II 激发光疗纳米医学，用于 TNBC 的时空特异性诊断和联合治疗。产生细胞毒性自由基并实现与氧无关的光子热力学治疗 (PTDT) 效果。NIR-II激光照射下，NIR-II荧光/光声双模态成像引导增强NIR-II PTT和Lip（PTQ/GA/AIPH）PTDT，可实现对深部TNBC的精确诊断和有效抑制，可忽略不计副作用。这项工作开发了一种有前途的 NIR-II 激发光疗纳米医学，用于 TNBC 的时空特异性诊断和联合治疗。

更新日期：2021-10-21

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11