The antimicrobial peptide database (APD) has served the antimicrobial peptide field for 18 years. Because it is widely used in research and education, this article documents database milestones and key events that have transformed it into the current form. A comparison is made for the APD peptide statistics between 2010 and 2020, validating the major database findings to date. We also describe new additions ranging from peptide entries to search functions. Of note, the APD also contains antimicrobial peptides from host microbiota, which are important in shaping immune systems and could be linked to a variety of human diseases. Finally, the database has been re-programmed to the web branding and latest security compliance of the University of Nebraska Medical Center. The reprogrammed APD can be accessed at https://aps.unmc.edu.

中文翻译：

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抗菌肽数据库 18 年来的演变：里程碑和新功能

抗菌肽数据库（APD）服务抗菌肽领域18年。由于它广泛用于研究和教育，本文记录了数据库里程碑和将其转变为当前形式的关键事件。对 2010 年和 2020 年的 APD 肽统计数据进行了比较，验证了迄今为止的主要数据库发现。我们还描述了从肽条目到搜索功能的新增功能。值得注意的是，APD 还含有来自宿主微生物群的抗菌肽，这对塑造免疫系统很重要，并可能与多种人类疾病有关。最后，该数据库已根据内布拉斯加大学医学中心的网络品牌和最新安全合规性重新编程。可以在 https://aps.unmc.edu 访问重新编程的 APD。