The identification and discrimination of snake venom are highly desired for timely clinical treatment. However, the complex components in snake venom make it a great challenge to achieve rapid and accurate identification. Inspired by the organism’s taste sensing system, a fluorescent sensor array that could differentiate snake venoms was fabricated. The interaction of snake venoms with different fluorescent dyes in the sensor array gave rich information, based on which efficient detection of complex snake venom was achieved. The main six proteins of snake venom in the same concentration, different concentrations, and their mixtures were identified with 100% accuracy. Furthermore, seven snake venoms belonging to different snake families were discriminated in PBS buffer and human plasma. Interferents of bovine serum albumin (BSA), thrombin, and transferrin (TRF) demonstrated the practicability of the fluorescent sensor array. This strategy of a multiresponse sensor array provides an effective method for accurate and rapid venom toxicology analysis, benefiting early and timely clinical diagnosis and treatment.

中文翻译：

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通过荧光鉴别识别蛇毒

蛇毒的识别和鉴别是及时临床治疗的迫切需要。然而，蛇毒中的复杂成分使得实现快速准确的识别成为一个巨大的挑战。受生物体味觉系统的启发，制造了一种可以区分蛇毒的荧光传感器阵列。蛇毒与传感器阵列中不同荧光染料的相互作用提供了丰富的信息，在此基础上实现了复杂蛇毒的高效检测。蛇毒的主要六种蛋白质在相同浓度、不同浓度及其混合物中的鉴定准确度为100%。此外，在 PBS 缓冲液和人血浆中区分了属于不同蛇科的七种蛇毒。牛血清白蛋白 (BSA)、凝血酶、和转铁蛋白（TRF）证明了荧光传感器阵列的实用性。这种多响应传感器阵列策略为准确、快速的毒液毒理学分析提供了一种有效的方法，有利于早期和及时​​的临床诊断和治疗。