Nitric oxide (NO) is omnipresent in the body and synthesized by 3 isoenzymes (nNOS, eNOS and iNOS), all detected in human skin. NO can be stored in a pool of compounds readily converted to NO following skin irradiation by UVR and blue light. This non-enzymatic (without NOS involvement) photolytic reaction mobilizes cutaneous stores of NO derivatives to the bloodstream, lowering blood pressure. However, with the likelihood of skin deleterious effects caused by UVR/blue light, safer wavelengths in the red/near-infrared (NIR) spectrum are becoming potential contenders to release cutaneous NO, possibly via NOS temperature-dependent effects. The use of red/NIR light to mobilize NO stores from the body's largest organ (the skin) is auspicious. This review focuses on UVR, blue, red, and NIR spectra and their capacity to release NO in human skin. PubMed and Google Scholar were used as article databases to find relevant publications related to this particular field.

一氧化氮 (NO) 在体内无处不在，由 3 种同工酶（nNOS、eNOS 和 iNOS）合成，均在人体皮肤中检测到。NO 可以储存在一组化合物中，在 UVR 和蓝光照射皮肤后很容易转化为 NO。这种非酶促（不涉及 NOS）光解反应将 NO 衍生物的皮肤储存调动到血液中，从而降低血压。然而，由于 UVR/蓝光可能对皮肤造成有害影响，红/近红外 (NIR) 光谱中更安全的波长正在成为释放皮肤 NO 的潜在竞争者，可能通过 NOS 温度依赖性效应。使用红光/近红外光调动身体最大器官（皮肤）的 NO 储存是吉祥的。本综述重点关注 UVR、蓝色、红色和 NIR 光谱及其在人体皮肤中释放 NO 的能力。