The solvent effects on C=O stretching vibrational frequency, ν(C=O), of ketoprofen (KETO) were studied experimentally using attenuated total reflection infrared spectroscopy (ATR-IR). The experimental ν(C=O) of KETO were correlated with empirical solvent parameters, including the Kirkwood–Bauer–Magat (KBM) equation, the acceptor numbers (ANs) of the solvents, the Swain equation, linear solvation energy relationships (LSERs), and the quadratic equation (QE). The solvent-induced ν(C=O) shifts of KETO displayed a better correlation with the LSER equation than with the KBM equation, ANs of the solvents, and the Swain equation. The linear effect of the solvent hydrogen-bond donor acidity (A_j) on ν(C=O) of KETO was found to be highly significant, whereas the hydrogen-bond acceptor basicity (B_j) and the interaction effect of A_j and B_j were not significant. It was also observed that the quadratic effects of A_j and B_j were slightly significant. Additionally, the linear effect of LSER parameters (π*, δ, α, and β) and the interaction effect of π*β on the ν(C=O) of KETO were highly significant.

使用衰减全反射红外光谱 (ATR-IR) 实验研究了溶剂对酮洛芬 (KETO) 的 C=O 伸缩振动频率 ν(C=O) 的影响。KETO 的实验 ν(C=O) 与经验溶剂参数相关，包括 Kirkwood-Bauer-Magat (KBM) 方程、溶剂的受体数 (ANs)、Swain 方程、线性溶剂化能关系 (LSERs) ，以及二次方程 (QE)。与 KBM 方程、溶剂的 AN 和 Swain 方程相比，溶剂引起的 KETO ν(C=O) 位移与 LSER 方程的相关性更好。发现溶剂氢键供体酸度 ( A _j ) 对 KETO ν(C=O)的线性影响非常显着，而氢键受体碱度 (B _j )，A _j和B _j的交互作用不显着。还观察到A _j和B _j的二次效应略微显着。此外，LSER 参数（π*、δ、α 和 β）的线性效应和 π*β 对 KETO ν(C=O) 的交互作用非常显着。