We are reporting 3 patients who presented acute zoster ophthalmicus (HZO), an activation of varicella-zoster virus, after mRNA anti-SARS-CoV-2 vaccination, seen directly or referred to our center. A 73-year-old woman with history of ocular sarcoidosis presented HZO in the right V1 dermatome 16 days after a single booster dose of vaccination (Pfizer BioNTech). A 69-year-old woman presented HZO in her V1 left dermatome, occurring 10 days after her first dose of Pfizer BioNTech vaccine. A 72-year-old woman with no history of autoimmune pathology, candidate for cataract surgery, presented 13 days after the first dose of a Moderna mRNA vaccine with an eruption in the left V1 dermatome. All patients presented the VZV infection after their first dose of a mRNA type of vaccine. Treatment with Valacyclovir 1000 mg × 3/ day for 7–14 days was efficient in all cases. Vaccines have been reported in the past to trigger different types of side effects such as viral or flu-like symptoms. It is only logical to note many different side effects for SARS-CoV-2 vaccines as the population vaccinated is exceeding any other number in history. VZV is one of the more severe side effects that can, however, be treated. It is quite obvious that, as far as mRNA vaccines are concerned, and probably also other anti-SARS-CoV-2 vaccines, that the benefit of vaccination certainly outweighs the possible but very low risk of ocular side effects that can mostly be treated.

中文翻译：

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SARS-CoV-2疫苗接种后水痘-带状疱疹病毒再激活导致眼部带状疱疹（HZO）——三例报告

我们报告了 3 名患者，他们在接种 mRNA 抗 SARS-CoV-2 疫苗后出现急性眼部带状疱疹 (HZO)，即水痘-带状疱疹病毒的激活，直接就诊或转诊至我们中心。一名有眼结节病病史的 73 岁女性在接种单次加强疫苗（辉瑞 BioNTech）后 16 天在右侧 V1 皮区出现 HZO。一名 69 岁女性在她的 V1 左侧皮区出现 HZO，发生在她第一剂辉瑞 BioNTech 疫苗后 10 天。一名 72 岁女性，无自身免疫病史，白内障手术候选人，在第一剂 Moderna mRNA 疫苗后 13 天就诊，左侧 V1 皮节出现皮疹。所有患者在首次接种 mRNA 类型的疫苗后均出现 VZV 感染。用伐昔洛韦 1000 mg × 3/天治疗 7-14 天在所有情况下都是有效的。过去曾报道过疫苗会引发不同类型的副作用，例如病毒或流感样症状。注意到 SARS-CoV-2 疫苗的许多不同副作用是合乎逻辑的，因为接种疫苗的人数超过了历史上的任何其他数字。然而，VZV 是可以治疗的更严重的副作用之一。很明显，就 mRNA 疫苗而言，可能还有其他抗 SARS-CoV-2 疫苗，疫苗接种的好处肯定超过了大多数可以治疗的可能但非常低的眼部副作用风险。注意到 SARS-CoV-2 疫苗的许多不同副作用是合乎逻辑的，因为接种疫苗的人数超过了历史上的任何其他数字。然而，VZV 是可以治疗的更严重的副作用之一。很明显，就 mRNA 疫苗而言，可能还有其他抗 SARS-CoV-2 疫苗，疫苗接种的好处肯定超过了大多数可以治疗的可能但非常低的眼部副作用风险。注意到 SARS-CoV-2 疫苗的许多不同副作用是合乎逻辑的，因为接种疫苗的人数超过了历史上的任何其他数字。然而，VZV 是可以治疗的更严重的副作用之一。很明显，就 mRNA 疫苗而言，可能还有其他抗 SARS-CoV-2 疫苗，疫苗接种的好处肯定超过了大多数可以治疗的可能但非常低的眼部副作用风险。