Pharma 4.0, a technology ecosystem in drug development analogous to Industry 4.0 in healthcare, is transforming the traditional approach to drug discovery and development, aligning product quality with less time to market, and creating intelligent stakeholder networks through effective collaborations. The wide range of potential Pharma 4.0 networks have produced several conceptualizations, which have led to a lack of clarity and definition. The main emphasis of this paper is on the clinical trial stage of drug development in the Pharma 4.0 era. It highlights the merged computerized technologies that are currently used in clinical research, and proposes a framework for integrating Pharma 4.0 technologies. The impact of and barriers to employing the proposed framework are discussed, highlighting its potential and some future research applications.

Pharma 4.0 是药物开发中的技术生态系统，类似于医疗保健中的工业 4.0，它正在改变药物发现和开发的传统方法，使产品质量与更短的上市时间保持一致，并通过有效的合作创建智能的利益相关者网络。广泛的潜在 Pharma 4.0 网络产生了一些概念化，导致缺乏明确性和定义。本文的重点是Pharma 4.0时代药物研发的临床试验阶段。它突出了目前在临床研究中使用的合并计算机化技术，并提出了一个整合 Pharma 4.0 技术的框架。讨论了使用拟议框架的影响和障碍，强调了其潜力和一些未来的研究应用。