Iron-Catalyzed Alkyne-Based Multicomponent Synthesis of Pyrimidines under Air,The Journal of Organic Chemistry

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Iron-Catalyzed Alkyne-Based Multicomponent Synthesis of Pyrimidines under Air
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2021-09-16 , DOI: 10.1021/acs.joc.1c00867
Rakesh Mondal ₁ , Gargi Chakraborty ₁ , Amit Kumar Guin ₁ , Susmita Sarkar ₁ , Nanda D Paul ₁

Affiliation

An iron-catalyzed sustainable, economically affordable, and eco-friendly synthetic protocol for the construction of various trisubstituted pyrimidines is described. A wide range of trisubstituted pyrimidines were prepared using a well-defined, easy to prepare, bench-stable, and phosphine-free iron catalyst featuring a redox-noninnocent tridentate arylazo pincer under comparatively mild aerobic conditions via dehydrogenative functionalization of alcohols with alkynes and amidines.

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