AgOTf/I2-Mediated Cyclization/Cross-Coupling/Isomerization of Enynones with Phosphorus Ylides: An Expedient Route to Stereoselective Synthesis of (E)-2-Alkenylfurans,The Journal of Organic Chemistry

当前位置： X-MOL 学术 › J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

AgOTf/I2-Mediated Cyclization/Cross-Coupling/Isomerization of Enynones with Phosphorus Ylides: An Expedient Route to Stereoselective Synthesis of (E)-2-Alkenylfurans
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2021-09-16 , DOI: 10.1021/acs.joc.1c01109
Ling Tang _{1,

2} , Yangyi Zhang _{1,

2} , Guisheng Deng _{1,

2}

Affiliation

Ag(I)-catalyzed cascade reactions involving enynone cyclization and cross-coupling with phosphorus ylides have been achieved for the first time. Subsequent treatment of the reaction mixture with I₂ afforded the corresponding (E)-α-alkenylfurans in 73–95% yields with excellent stereoselectively. A reasonable mechanism has been proposed.

中文翻译：

AgOTf/I2 介导的烯酮与磷叶立德的环化/交叉偶联/异构化：立体选择性合成 (E)-2-烯基呋喃的便捷途径

首次实现了涉及烯炔酮环化和与磷叶立德交叉偶联的 Ag(I) 催化级联反应。随后用 I ₂处理反应混合物，以 73-95% 的收率得到相应的 ( E )-α-烯基呋喃，并具有优异的立体选择性。提出了合理的机制。

更新日期：2021-10-01

点击分享查看原文

点击收藏

阅读更多本刊最新论文