Metal-Free Solvent Promoted Oxidation of Benzylic Secondary Amines to Nitrones with H2O2,The Journal of Organic Chemistry

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Metal-Free Solvent Promoted Oxidation of Benzylic Secondary Amines to Nitrones with H2O2
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2021-09-16 , DOI: 10.1021/acs.joc.1c01888
Álisson Silva Granato _{1,

2} , Giovanni Wilson Amarante ₂ , Javier Adrio _{1,

3}

Affiliation

An environmentally benign protocol for the generation of nitrones from benzylic secondary amines via catalyst-free oxidation of secondary amines using H₂O₂ in MeOH or CH₃CN is described. This methodology provides a selective access to a variety of C-aryl nitrones in yields of 60 to 93%. Several studies have been performed to shed light on the reaction mechanism and the role of the solvent.

中文翻译：

无金属溶剂促进 H2O2 氧化苄基仲胺生成硝酮

描述了一种环境友好的方案，用于通过使用MeOH 或 CH _{3 CN 中的 H}₂ O ₂进行仲胺的无催化剂氧化，从苄基仲胺生成硝酮。该方法可以选择性地获得多种 C-芳基硝酮，产率为 60% 至 93%。已经进行了几项研究来阐明反应机理和溶剂的作用。

更新日期：2021-10-01

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