We report the design and synthesis of a series of three-dimensional (3D) covalent organic frameworks (COFs) as immunogenic cell death (ICD) inducers for cancer immunotherapy. Three triple-topic amine building blocks, inactive to inducing ICD, were used to construct three COFs, COF-607, COF-608, and COF-609, with outstanding ICD eliciting efficiency. Mechanism studies revealed that after linking these ICD inert monomers into the COF backbone, the optical properties of these COFs could be systematically tuned to achieve excellent reactive oxygen species (ROS) production performance. This combined with 3D cross-linked pores, mimicking lung structure, favor the exchange and diffusion of oxygen and ROS, leading to excellent inducing ICD efficacy. One member, COF-609, is capable of triggering abscopal and long-lasting immune memory effects in a mouse model of breast cancer with >95% mice survival after being treated with COF-609+αCD47 for 110 days.

中文翻译：

---

具有交联孔的三维共价有机框架用于有效的癌症免疫治疗

我们报告了一系列三维 (3D) 共价有机框架 (COF) 作为癌症免疫治疗的免疫原性细胞死亡 (ICD) 诱导剂的设计和合成。三个三重胺结构单元对诱导 ICD 无活性，用于构建三个 COF，COF-607、COF-608 和 COF-609，具有出色的 ICD 诱导效率。机理研究表明，将这些 ICD 惰性单体连接到 COF 主链后，可以系统地调整这些 COF 的光学特性，以实现优异的活性氧 (ROS) 生产性能。这与模拟肺结构的 3D 交联孔相结合，有利于氧气和 ROS 的交换和扩散，从而具有出色的诱导 ICD 功效。一名成员，COF-609，