当前位置：
X-MOL 学术
›
Eur. J. Org. Chem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Investigating the Individual Importance of the Pam2Cys Ester Motifs on TLR2 Activity
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-09-15 , DOI: 10.1002/ejoc.202101055 Margaret Anne Brimble 1 , Benjamin L Lu 2 , Freda F Li 2 , Inken D Kelch 3 , Geoffrey M Williams 2 , P Rod Dunbar 3
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-09-15 , DOI: 10.1002/ejoc.202101055 Margaret Anne Brimble 1 , Benjamin L Lu 2 , Freda F Li 2 , Inken D Kelch 3 , Geoffrey M Williams 2 , P Rod Dunbar 3
Affiliation
|
Analogues of Pam2Cys, the traditional TLR2 ligand, were designed to probe structure–activity relationships, namely, the individual importance of each ester carbonyl to TLR2 activity is called in to question. Analogues possess ethers in place of either one or other of the ester functional groups. Access to these analogues is provided by union of classical enantiomerically-enriched starting materials through the key S-alkylation of a protected cysteine.
中文翻译：
研究 Pam2Cys 酯基序对 TLR2 活性的个体重要性
Pam 2 Cys 的类似物是传统的 TLR2 配体，旨在探测结构-活性关系，即每个酯羰基对 TLR2 活性的个别重要性受到质疑。类似物具有代替一个或其他酯官能团的醚。通过受保护的半胱氨酸的关键S-烷基化结合经典的富含对映异构体的起始材料，提供了获得这些类似物的途径。
更新日期：2021-10-19
中文翻译：
研究 Pam2Cys 酯基序对 TLR2 活性的个体重要性
Pam 2 Cys 的类似物是传统的 TLR2 配体，旨在探测结构-活性关系，即每个酯羰基对 TLR2 活性的个别重要性受到质疑。类似物具有代替一个或其他酯官能团的醚。通过受保护的半胱氨酸的关键S-烷基化结合经典的富含对映异构体的起始材料，提供了获得这些类似物的途径。
京公网安备 11010802027423号