The effects of cerebral amyloidopathy on regional glucose metabolism in older adults with depression and mild cognitive impairment while performing memory tasks,European Journal of Neuroscience

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The effects of cerebral amyloidopathy on regional glucose metabolism in older adults with depression and mild cognitive impairment while performing memory tasks
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2021-09-15 , DOI: 10.1111/ejn.15461
Eun Seong Lee ₁ , HyunChul Youn ₂ , Won Seok William Hyung ₃ , Sangil Suh ₄ , Cheol E Han ₅ , Jae Seon Eo ₁ , Hyun-Ghang Jeong _{3,

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Affiliation

Co-occurring depression and mild cognitive impairment (MCI) in older adults are important because they have a high risk of conversion to dementia. In the present study, task-related F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) was used to analyse older adults with concomitant depression and MCI. We recruited 20 older adults with simultaneous depression and MCI and 10 older adults with normal cognition (NC). The Verbal Paired Associates test and digit span test were used for the task-related FDG-PET. The 20 older adults with depression and MCI were classified into two groups based on the F-18 florbetaben PET results: depressed MCI patients with (LLD-MCI-A[+]; n = 11) and without amyloid accumulation (LLD-MCI-A[−]; n = 9). Reduced regional cerebral glucose metabolism (rCMglc) in the left superior frontal region was observed in the LLD-MCI-A(−) group compared with the NC group. Analyses of the NC and LLD-MCI-A(+) groups showed significantly decreased rCMglc in the right inferior parietal and left middle frontal regions in the LLD-MCI-A(+) group. rCMglc in the left precuneus was lower in the LLD-MCI-A(+) group than in the LLD-MCI-A(−) group. Significant correlations between the rCMglc in the right inferior parietal/left precuneus regions and memory task scores were observed based on correlation analyses of NC and LLD-MCI-A(+) groups. The findings in the present study indicate the presence of amyloid accumulation influences glucose metabolism in depressed elderly subjects with MCI while performing cognitive tasks. Task-related FDG-PET examinations may help differentiate MCI associated with depression from comorbid depression in patients with prodromal Alzheimer's disease.

中文翻译：

脑淀粉样变对抑郁和轻度认知障碍老年人在执行记忆任务时区域糖代谢的影响

老年人同时发生的抑郁症和轻度认知障碍 (MCI) 很重要，因为他们转化为痴呆症的风险很高。在本研究中，任务相关的 F-18 氟脱氧葡萄糖正电子发射断层扫描 (FDG-PET) 用于分析伴有抑郁症和 MCI 的老年人。我们招募了 20 名同时患有抑郁症和 MCI 的老年人和 10 名认知正常 (NC) 的老年人。Verbal Paired Associates 测试和数字跨度测试用于与任务相关的 FDG-PET。根据 F-18 florbetaben PET 结果将 20 名患有抑郁症和 MCI 的老年人分为两组：患有 (LLD-MCI-A[+]; n = 11) 和没有淀粉样蛋白积聚 (LLD-MCI- A[-]; n = 9）。与 NC 组相比，在 LLD-MCI-A(-) 组中观察到左上额叶区域的局部脑葡萄糖代谢 (rCMglc) 降低。NC 和 LLD-MCI-A(+) 组的分析表明，LLD-MCI-A(+) 组右侧下顶叶和左侧中额叶区域的 rCMglc 显着降低。LLD-MCI-A(+) 组左侧楔前叶的 rCMglc 低于 LLD-MCI-A(-) 组。基于 NC 和 LLD-MCI-A(+) 组的相关性分析，观察到右下顶叶/左楔前叶区域的 rCMglc 与记忆任务分数之间存在显着相关性。本研究的结果表明，淀粉样蛋白积累的存在会影响患有 MCI 的抑郁老年受试者在执行认知任务时的葡萄糖代谢。

更新日期：2021-10-20

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