Identification and characterization of metamorphic proteins: Current and future perspectives,Biopolymers

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Identification and characterization of metamorphic proteins: Current and future perspectives
Biopolymers ( IF 3.2 ) Pub Date : 2021-09-16 , DOI: 10.1002/bip.23473
Madhurima Das ₁ , Nanhao Chen ₂ , Andy LiWang _{1,

3,

4,

5,

6} , Lee-Ping Wang ₂

Affiliation

Proteins that can reversibly alternate between distinctly different folds under native conditions are described as being metamorphic. The “metamorphome” is the collection of all metamorphic proteins in the proteome, but it remains unknown the extent to which the proteome is populated by this class of proteins. We propose that uncovering the metamorphome will require a synergy of computational screening of protein sequences to identify potential metamorphic behavior and validation through experimental techniques. This perspective discusses computational and experimental approaches that are currently used to predict and characterize metamorphic proteins as well as the need for developing improved methodologies. Since metamorphic proteins act as molecular switches, understanding their properties and behavior could lead to novel applications of these proteins as sensors in biological or environmental contexts.

中文翻译：

变质蛋白的鉴定和表征：当前和未来的观点

在天然条件下可以在明显不同的折叠之间可逆地交替的蛋白质被描述为变质的。“变质组”是蛋白质组中所有变质蛋白质的集合，但蛋白质组被这类蛋白质填充的程度仍然未知。我们建议揭示变质组将需要对蛋白质序列进行计算筛选的协同作用，以识别潜在的变质行为并通过实验技术进行验证。这一观点讨论了目前用于预测和表征变质蛋白的计算和实验方法，以及开发改进方法的必要性。由于变质蛋白充当分子开关，

更新日期：2021-10-25

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