Prostate tumors of native men from West Africa show biologically distinct pathways—A comparative genomic study,The Prostate

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Prostate tumors of native men from West Africa show biologically distinct pathways—A comparative genomic study
The Prostate ( IF 2.6 ) Pub Date : 2021-09-16 , DOI: 10.1002/pros.24238
Kosj Yamoah _{1,

2} , Francis A Asamoah ₃ , Afua O D Abrahams ₄ , Shivanshu Awasthi ₂ , James E Mensah ₅ , Jasreman Dhillon ₆ , Brandon A Mahal ₇ , Serigne Magueye Gueye ₈ , Mohamed Jalloh ₈ , Sahar J Farahani ₉ , Priti Lal ₁₀ , Timothy R Rebbeck ₁₁ , Joel Yarney ₃

Affiliation

Department of Radiation Oncology, H. Lee Moffitt Cancer Center, Tampa, Florida, USA.
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, Florida, USA.
National Center for Radiotherapy, Oncology and Nuclear Medicine, Korle Bu Teaching Hospital Accra, Accra, Ghana.
Department of Pathology, University of Ghana Medical School, Korle bu Teaching Hospital, Accra, Ghana.
Department of Surgery, University of Ghana Medical School, Korle bu Teaching Hospital, Accra, Ghana.
Department of Pathology, H. Lee Moffitt Cancer Center, Tampa, Florida, USA.
Department of Radiation Oncology, University of Miami, Miami, Florida, USA.
Hospital General Idrissa Pouye, Dakar, Senegal.
Department of Pathology, Stony Brook University, New York city, New York, USA.
Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Dana Farber Cancer Institute and Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.

Native African men (NAM) experience a disproportionate burden of prostate cancer (PCa) and have higher mortality rates compared to European American men (EAM). While socioeconomic status has been implicated as a driver of this disparity, little is known about the genomic mechanisms and distinct biological pathways that are associated with PCa of native men of African origin.

中文翻译：

西非土著男性的前列腺肿瘤显示出生物学上不同的途径——一项比较基因组研究

与欧洲裔美国男性 (EAM) 相比，非洲原住民男性 (NAM) 承受着不成比例的前列腺癌 (PCa) 负担，并且死亡率更高。虽然社会经济地位被认为是这种差异的驱动因素，但人们对与非洲原住民 PCa 相关的基因组机制和独特的生物学途径知之甚少。

更新日期：2021-11-03

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