Signaling networks in B cell development and related therapeutic strategies,Journal of Leukocyte Biology

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Signaling networks in B cell development and related therapeutic strategies
Journal of Leukocyte Biology ( IF 3.6 ) Pub Date : 2021-09-16 , DOI: 10.1002/jlb.2ru0221-088rrr
Anwen Ren ₁ , Jianxuan Sun ₂ , Wei Yin ₃ , Lisa S Westerberg ₄ , Heather Miller ₅ , Pamela Lee ₆ , Fabio Candotti ₇ , Fei Guan ₁ , Jiahui Lei ₁ , Quan Gong _{8,

9} , Yan Chen ₁₀ , Chaohong Liu ₁

Affiliation

Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Microbiology Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
The Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Division of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Department of Immunology, School of Medicine, Yangtze University, Jingzhou, China.
Clinical Molecular Immunology Center, School of Medicine, Yangtze University, Jingzhou, China.
The Second Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.

B cells are essential for Ab production during humoral immune responses. From decades of B cell research, there is now a detailed understanding of B cell subsets, development, functions, and most importantly, signaling pathways. The complicated pathways in B cells and their interactions with each other are stage-dependent, varying with surface marker expression during B cell development. With the increasing understanding of B cell development and signaling pathways, the mechanisms underlying B cell related diseases are being unraveled as well, making it possible to provide more precise and effective treatments. In this review, we describe several essential and recently discovered signaling pathways in B cell development and take a look at newly developed therapeutic strategies targeted at B cell signaling.

中文翻译：

B细胞发育中的信号网络及相关治疗策略

B 细胞在体液免疫反应过程中对抗体的产生至关重要。经过数十年的 B 细胞研究，现在对 B 细胞亚群、发育、功能以及最重要的信号通路有了详细的了解。B 细胞中复杂的通路及其相互作用是阶段依赖性的，在 B 细胞发育过程中随表面标志物的表达而变化。随着对 B 细胞发育和信号通路的了解越来越多，B 细胞相关疾病的潜在机制也正在被揭示，这使得提供更精确和有效的治疗成为可能。在这篇综述中，我们描述了 B 细胞发育中几个重要的和最近发现的信号通路，并着眼于新开发的针对 B 细胞信号传导的治疗策略。

更新日期：2021-09-16

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