Soluble CD127 potentiates IL-7 activity in vivo in healthy mice,Immunity, Inflammation and Disease

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Soluble CD127 potentiates IL-7 activity in vivo in healthy mice
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2021-09-15 , DOI: 10.1002/iid3.530
Nawaf A Aloufi _{1,

2,

3} , Alaa K Ali ₁ , Stephanie C Burke Schinkel ₃ , Bengisu Molyer _{1,

3} , Priscila O Barros ₃ , Joanne E McBane _{3,

4} , Seung-Hwan Lee _{1,

5} , Jonathan B Angel _{1,

3,

5,

6}

Affiliation

Soluble forms of cytokine receptors can be involved in the endogenous regulation of cytokine activity. Soluble interleukin 7 receptor α (sCD127) naturally binds IL-7, therefore there is interest in its potential application as an immunotherapeutic agent to regulate IL-7. With the hypothesis that sCD127 enhances IL-7 activity, thus promoting T-cell proliferation in vivo, we sought to assess the effect of sCD127, IL-7 or IL-7 + sCD127 treatment on CD4⁺ and CD8⁺ T-cells in the blood and spleen of mice.

中文翻译：

可溶性 CD127 在健康小鼠体内增强 IL-7 活性

细胞因子受体的可溶性形式可以参与细胞因子活性的内源性调节。可溶性白细胞介素 7 受体 α (sCD127) 与 IL-7 天然结合，因此人们对其作为免疫治疗剂调节 IL-7 的潜在应用很感兴趣。假设 sCD127 增强 IL-7 活性，从而促进体内 T 细胞增殖，我们试图评估 sCD127、IL-7 或 IL-7 + sCD127 处理对 CD4 ⁺和 CD8 ⁺ T 细胞的影响小鼠的血液和脾脏。

更新日期：2021-11-13

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