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Soluble CD127 potentiates IL-7 activity in vivo in healthy mice
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2021-09-15 , DOI: 10.1002/iid3.530
Nawaf A Aloufi 1, 2, 3 , Alaa K Ali 1 , Stephanie C Burke Schinkel 3 , Bengisu Molyer 1, 3 , Priscila O Barros 3 , Joanne E McBane 3, 4 , Seung-Hwan Lee 1, 5 , Jonathan B Angel 1, 3, 5, 6
Affiliation  

Soluble forms of cytokine receptors can be involved in the endogenous regulation of cytokine activity. Soluble interleukin 7 receptor α (sCD127) naturally binds IL-7, therefore there is interest in its potential application as an immunotherapeutic agent to regulate IL-7. With the hypothesis that sCD127 enhances IL-7 activity, thus promoting T-cell proliferation in vivo, we sought to assess the effect of sCD127, IL-7 or IL-7 + sCD127 treatment on CD4+ and CD8+ T-cells in the blood and spleen of mice.

中文翻译:

可溶性 CD127 在健康小鼠体内增强 IL-7 活性

细胞因子受体的可溶性形式可以参与细胞因子活性的内源性调节。可溶性白细胞介素 7 受体 α (sCD127) 与 IL-7 天然结合,因此人们对其作为免疫治疗剂调节 IL-7 的潜在应用很感兴趣。假设 sCD127 增强 IL-7 活性,从而促进体内 T 细胞增殖,我们试图评估 sCD127、IL-7 或 IL-7 + sCD127 处理对 CD4 +和 CD8 + T 细胞的影响小鼠的血液和脾脏。
更新日期:2021-11-13
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