Irisin is a recently discovered adipomyokine involved in the regulation of glucose and lipid, which also exhibits anti-inflammatory and neuroprotective properties. Here we aimed to compare irisin peripheral levels between individuals with behavioral variant frontotemporal dementia (bvFTD) and cognitively healthy matched controls, in addition to investigating whether there is a correlation between irisin and pro-inflammatory cytokines (IL-6 and TNF) concentrations. Twenty-nine individuals participated in this study, being 18 patients with probable bvFTD and 11 controls. Irisin, IL-6 and TNF levels were measured in EDTA plasma through ELISA. There was no difference of the levels of irisin between the groups (p = 0.964). However, in the bvFTD, but not in control group, the levels of irisin were positively correlated with the concentration of IL-6 (r = 0.637, p = 0.006) and TNF (r = 0.517, p = 0.034). The results suggest that the production of irisin in bvFTD could be related to chronic inflammatory and neurodegenerative states in these patients.

鸢尾素是最近发现的一种脂肪肌因子，参与葡萄糖和脂质的调节，它还表现出抗炎和神经保护特性。在这里，除了调查鸢尾素和促炎细胞因子（IL-6 和 TNF）浓度之间是否存在相关性之外，我们还旨在比较行为变异额颞叶痴呆 (bvFTD) 和认知健康匹配对照之间的鸢尾素外周水平。29 人参与了这项研究，其中 18 名可能患有 bvFTD 的患者和 11 名对照者。通过ELISA在EDTA血浆中测量鸢尾素、IL-6和TNF水平。组间鸢尾素水平没有差异（p = 0.964）。然而，在 bvFTD 中，而不是在对照组中，鸢尾素水平与IL-6（r=0.637，p=0.006）和TNF（r=0.517，p=0.034）浓度呈正相关。结果表明，bvFTD 中鸢尾素的产生可能与这些患者的慢性炎症和神经退行性状态有关。