Pectin grafted polyacrylic copolymer hydrogels were made by free radical crosslink copolymerization of acrylic acid (AA) and acrylamide (AM) in an aqueous solution of pectin. N′N-methylene bis acrylamide (MBA) was used as a crosslinker. During the polymerization reaction the attapulgite (APG) filler was also incorporated in situ into the network of the copolymer gel. Several filled hydrogels were prepared by varying the amount of pectin and APG filler. These hydrogels were characterized by FTIR, ¹³C NMR, XRD, TGA, SEM, mechanical properties, DMA, swelling, diffusion characteristics and network parameters. The release kinetics of a model drug diltiazem hydrochloride (DT) was studied with these hydrogels. The wt% of pectin, APG and MBA was optimized with a central composite design (CCD) model of response surface methodology (RSM) with equilibrium swelling ratio (ESR), drug adsorption (mg/100 mg gel) and drug release% in 16 h as response. Accordingly, the hydrogel prepared with 5:1 AA:AM molar ratio, 25 wt% monomer concentration, 1% each of initiator and MBA concentration, 18 wt% pectin and 2 wt% APG showed an optimized ESR of 17.75, drug loading of 27.58 and a drug release % of 92.5 in 16 h at a solution pH of 7.4.

果胶接枝聚丙烯酸共聚物水凝胶是通过丙烯酸（AA）和丙烯酰胺（AM）在果胶水溶液中的自由基交联共聚制备的。Ñ ' Ñ亚甲基双丙烯酰胺（MBA）被用作交联剂。在聚合反应期间，凹凸棒石 (APG) 填料也原位加入共聚物凝胶的网络中。通过改变果胶和 APG 填料的量制备了几种填充水凝胶。这些水凝胶通过 FTIR 表征，¹³C NMR、XRD、TGA、SEM、机械性能、DMA、溶胀、扩散特性和网络参数。用这些水凝胶研究了模型药物盐酸地尔硫卓 (DT) 的释放动力学。果胶、APG 和 MBA 的 wt% 使用响应面法 (RSM) 的中心复合设计 (CCD) 模型进行了优化，该模型具有平衡溶胀比 (ESR)、药物吸附 (mg/100 mg 凝胶) 和药物释放% 16 h 作为回应。因此，以 5:1 AA:AM 摩尔比、25 wt% 单体浓度、1% 引发剂和 MBA 浓度、18 wt% 果胶和 2 wt% APG 制备的水凝胶显示优化的 ESR 为 17.75，载药量为 27.58在 7.4 的溶液 pH 值下，16 小时内的药物释放百分比为 92.5。