HLA-B54 is an independent risk factor for pneumonia in Japanese patients with interstitial lung disease: A multicenter retrospective cohort study,Respiratory Medicine

当前位置： X-MOL 学术 › Resp. Med. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

HLA-B54 is an independent risk factor for pneumonia in Japanese patients with interstitial lung disease: A multicenter retrospective cohort study
Respiratory Medicine ( IF 3.5 ) Pub Date : 2021-09-16 , DOI: 10.1016/j.rmed.2021.106612
Noriho Sakamoto ₁ , Hiroshi Ishimoto ₁ , Masahiro Tahara ₂ , Takashi Kido ₁ , Atsuko Hara ₁ , Takuto Miyamura ₁ , Daisuke Okuno ₁ , Takatomo Tokito ₁ , Sumako Yoshioka ₃ , Shimpei Morimoto ₄ , Takahiro Takazono ₅ , Kazuko Yamamoto ₁ , Hiroyuki Yamaguchi ₁ , Yasushi Obase ₁ , Yuji Ishimatsu ₆ , Kazuhiro Yatera ₂ , Hiroshi Mukae ₁

Affiliation

Purpose

Pneumonia is a major cause of respiratory-related hospitalization and an important prognostic factor in patients with chronic interstitial lung disease (ILD). However, the relationship between the incidence of pneumonia and human leukocyte antigen (HLA) serotype has not been fully elucidated. Therefore, this study aimed to determine if there is a relationship between HLA serotype and the incidence of pneumonia in Japanese patients with ILD.

Methods

The medical records of patients with ILD treated at any of three centers in Japan were reviewed to determine their HLA-A and HLA-B serotypes. The characteristics of patients with and without pneumonia were compared. Cox regression analysis was performed to identify risk factors for pneumonia and death in these patients.

Results

One hundred and forty-four patients with ILD (pneumonia group, n = 27; non-pneumonia group, n = 117) and complete HLA serology data available were included. HLA-B54 positivity was significantly more common in the pneumonia group than in the non-pneumonia group (37.0% vs. 15.4%, p = 0.010). HLA-B54 positivity was also a significant risk factor for pneumonia (hazard ratio [HR] 4.166, 95% confidence interval [CI] 1.862–9.320, p = 0.001) and death (HR 4.050, 95% CI 1.581–10.374, p = 0.004) in patients with ILD. Furthermore, HLA-B54 positivity was a significant risk factor for pneumonia (HR 3.964, 95% CI 1.392–11.090, p = 0.010) and death (HR 8.131, 95% CI 1.763–37.494, p = 0.007) in patients with idiopathic pulmonary fibrosis.

Conclusion

HLA-B54 positivity was a significant risk factor for pneumonia and death in patients with ILD, including those with idiopathic pulmonary fibrosis.

中文翻译：

HLA-B54 是日本间质性肺病患者肺炎的独立危险因素：一项多中心回顾性队列研究

目的

肺炎是呼吸相关住院的主要原因，也是慢性间质性肺病（ILD）患者的重要预后因素。然而，肺炎的发病率与人类白细胞抗原（HLA）血清型之间的关系尚未完全阐明。因此，本研究旨在确定 HLA 血清型与日本 ILD 患者肺炎发病率之间是否存在关系。

方法

审查了在日本三个中心中的任何一个接受治疗的 ILD 患者的医疗记录，以确定他们的 HLA-A 和 HLA-B 血清型。比较有和没有肺炎的患者的特征。进行 Cox 回归分析以确定这些患者肺炎和死亡的危险因素。

结果

纳入了 144 名 ILD 患者（肺炎组，n = 27；非肺炎组，n = 117）和完整的 HLA 血清学数据。肺炎组的 HLA-B54 阳性率明显高于非肺炎组（37.0% 对 15.4%，p = 0.010）。HLA-B54 阳性也是肺炎（风险比 [HR] 4.166，95% 置信区间 [CI] 1.862–9.320，p = 0.001）和死亡（HR 4.050，95% CI 1.581–10.374，p = 0.004) 在 ILD 患者中。此外，HLA-B54 阳性是特发性肺病患者肺炎（HR 3.964, 95% CI 1.392–11.090, p = 0.010）和死亡（HR 8.131, 95% CI 1.763–37.494, p = 0.007）的重要危险因素。纤维化。