New variants of SARS-CoV-2 Alpha (B.1.1.7); Beta (B.1.351) Gamma (P.1) and Delta (B.1.617.2) quickly spread in the UK, South Africa, Brazil and India, respectively. To address whether mutations in SARS-CoV-2 RBD spike protein could affect virus infectivity, peptides containing RBD amino acids mutations have been constructed and interacted with human ACE2 by computational methods. Our results suggest that mutations in RBD amino acids K417, E484, L452, T478 and N501 are expressively increasing the affinity of this protein with human angiotensin-converting enzyme 2 (ACE2), consequently, variants Alpha (B.1.1.7), Beta (B1.351), Gamma (P.1) and Delta (B.1.617.2) could be more infective in human cells compared with SARS-CoV-2 isolated in Wuhan-2019 and the Gamma and Delta variants could be the most infective among them.

SARS-CoV-2 Alpha 的新变种 (B.1.1.7)；Beta (B.1.351) Gamma (P.1) 和 Delta (B.1.617.2) 分别在英国、南非、巴西和印度迅速传播。为了解决 SARS-CoV-2 RBD 刺突蛋白的突变是否会影响病毒感染性，已经构建了含有 RBD 氨基酸突变的肽并通过计算方法与人类 ACE2 相互作用。我们的结果表明，RBD 氨基酸 K417、E484、L452、T478 和 N501 的突变显着增加了该蛋白质与人血管紧张素转换酶 2 (ACE2) 的亲和力，因此，变体 Alpha (B.1.1.7)、Beta (B1.351)、Gamma (P.1) 和 Delta (B.1.617.2) 与 2019 年武汉分离的 SARS-CoV-2 相比，可能在人体细胞中更具传染性，并且 Gamma 和 Delta 变体可能是最具感染力的其中具有感染力。