Abstract

Today, the world moves towards wireless communication. Broadly, so far it is all about communication between something of the size one can keep in hand like mobile phone. Current trend in miniaturizing the device capable to remote control and communication requires new solution in physics, chemistry and engineering. There is a growing demand to make microstructures enabling remote communication. Physics offers various remote signalling such as ultrasound, magnetic field, light and electromagnetic irradiation of wide spectrum including radio waves. Obviously, the fabricated microstructures should be susceptible to ones or few of these remote physical signalling. Modern approaches in Materials Science offers some solutions where micron and submicron structures could have multimodal function and could be guided and interrogated by external device. Looking from medical perspectives, the number of unmet needs in biomedicine require local solution, namely local treatment of diseases where the externally guided vehicles are unable to reach the side of interest, explore it via sensing principle interrogate with external device and deploy of therapeutic drugs. The challenge is whether we can label single cell in organism and follow their movement or have handful number of vehicle with encapsulated cargo circulating in the body but retained via remote controlled. The task for materials science in this aspect is to fabricate a vehicle carrying therapeutic, made of materials approved for human use and contain elements susceptible for remote control. In our work we review the most recent approaches to explore delivery systems enabling remote guidance. Our focus is in particular on layer-by-layer capsules which have been introduced as technology to tailor various function in one entity. Apart of layer-by-layer method we are going to consider so called polymer microchambers technique and formation of capsules exploring pattern surfaces as well as use porous vaterite particles where the therapeutic effect is reached by ultrasound, for example.

中文翻译：

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遥控输送系统。迈向医疗应用之路

摘要

今天，世界正朝着无线通信的方向发展。从广义上讲，到目前为止，一切都是关于像手机一样可以随身携带的大小的东西之间的通信。小型化能够远程控制和通信的设备的当前趋势需要物理、化学和工程方面的新解决方案。制造能够实现远程通信的微结构的需求不断增长。物理学提供各种远程信号，例如超声波、磁场、光和包括无线电波在内的广谱电磁辐射。显然，制造的微结构应该容易受到这些远程物理信号中的一个或几个的影响。材料科学的现代方法提供了一些解决方案，其中微米和亚微米结构可以具有多模态功能，并且可以由外部设备引导和询问。从医学的角度来看，生物医学中未满足的需求数量需要局部解决，即对外部引导车辆无法到达感兴趣的一侧的疾病进行局部治疗，通过传感原理与外部设备询问并部署治疗药物。挑战在于我们是否可以标记生物体中的单个细胞并跟踪它们的运动，或者是否有少数带有封装货物的车辆在体内循环但通过远程控制保留。材料科学在这方面的任务是制造一种载有治疗剂的车辆，由批准用于人类使用的材料制成，并包含易于远程控制的元素。在我们的工作中，我们回顾了探索支持远程指导的交付系统的最新方法。我们特别关注逐层胶囊，这些胶囊已被引入作为在一个实体中定制各种功能的技术。除了逐层方法，我们将考虑所谓的聚合物微室技术和探索图案表面的胶囊的形成，以及使用多孔球霰石颗粒，例如通过超声波达到治疗效果.