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BRAIN UK: Accessing NHS tissue archives for neuroscience research
Neuropathology and Applied Neurobiology ( IF 4.0 ) Pub Date : 2021-09-15 , DOI: 10.1111/nan.12766 James A R Nicoll 1, 2 , Tabitha Bloom 1 , Amelia Clarke 1 , Delphine Boche 1 , David Hilton 3
Neuropathology and Applied Neurobiology ( IF 4.0 ) Pub Date : 2021-09-15 , DOI: 10.1111/nan.12766 James A R Nicoll 1, 2 , Tabitha Bloom 1 , Amelia Clarke 1 , Delphine Boche 1 , David Hilton 3
Affiliation
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The purpose of BRAIN UK (the UK BRain Archive Information Network) is to make the very extensive and comprehensive National Health Service (NHS) Neuropathology archives available to the national and international neuroscience research community. The archives comprise samples of tumours and a wide range of other neurological disorders, not only from the brain but also spinal cord, peripheral nerve, muscle, eye and other organs when relevant. BRAIN UK was founded after the recognition of the importance of this large tissue resource, which was not previously readily accessible for research use. BRAIN UK has successfully engaged the majority of the regional clinical neuroscience centres in the United Kingdom to produce a centralised database of the extensive autopsy and biopsy archive. Together with a simple application process and its broad ethical approval, BRAIN UK offers researchers easy access to most of the national archives of neurological tissues and tumours (http://www.brain-uk.org). The range of tissues available reflects the spectrum of disease in society, including many conditions not covered by disease-specific brain banks, and also allows relatively large numbers of cases of uncommon conditions to be studied. BRAIN UK has supported 141 studies (2010–2020) that have generated 70 publications employing methodology as diverse as morphometrics, genetics, proteomics and methylomics. Tissue samples that would otherwise have been unused have supported valuable neuroscience research. The importance of this unique resource will only increase as molecular techniques applicable to human tissues continue to develop and technical advances permit large-scale high-throughput studies.
中文翻译：
BRAIN UK：访问 NHS 组织档案以进行神经科学研究
BRAIN UK（英国大脑档案信息网络）的目的是向国家和国际神经科学研究界提供非常广泛和全面的国家卫生服务 (NHS) 神经病理学档案。档案包括肿瘤和广泛的其他神经系统疾病的样本，不仅来自大脑，还来自脊髓、周围神经、肌肉、眼睛和其他相关器官。BRAIN UK 是在认识到这种大型组织资源的重要性之后成立的，而这种资源以前不容易用于研究用途。BRAIN UK 已成功与英国的大多数区域临床神经科学中心合作，制作了一个包含大量尸检和活检档案的集中式数据库。连同简单的申请流程和广泛的伦理批准，BRAIN UK 使研究人员可以轻松访问大多数国家神经组织和肿瘤档案 (http://www.brain-uk.org)。可用组织的范围反映了社会疾病的范围，包括疾病特异性脑库未涵盖的许多疾病，并且还允许研究相对大量的罕见疾病病例。BRAIN UK 支持了 141 项研究（2010-2020 年），这些研究产生了 70 篇出版物，采用了形态测量学、遗传学、蛋白质组学和甲基组学等多种方法。原本不会被使用的组织样本支持了有价值的神经科学研究。
更新日期：2021-09-15
中文翻译：
BRAIN UK：访问 NHS 组织档案以进行神经科学研究
BRAIN UK（英国大脑档案信息网络）的目的是向国家和国际神经科学研究界提供非常广泛和全面的国家卫生服务 (NHS) 神经病理学档案。档案包括肿瘤和广泛的其他神经系统疾病的样本，不仅来自大脑，还来自脊髓、周围神经、肌肉、眼睛和其他相关器官。BRAIN UK 是在认识到这种大型组织资源的重要性之后成立的，而这种资源以前不容易用于研究用途。BRAIN UK 已成功与英国的大多数区域临床神经科学中心合作，制作了一个包含大量尸检和活检档案的集中式数据库。连同简单的申请流程和广泛的伦理批准，BRAIN UK 使研究人员可以轻松访问大多数国家神经组织和肿瘤档案 (http://www.brain-uk.org)。可用组织的范围反映了社会疾病的范围，包括疾病特异性脑库未涵盖的许多疾病，并且还允许研究相对大量的罕见疾病病例。BRAIN UK 支持了 141 项研究（2010-2020 年），这些研究产生了 70 篇出版物，采用了形态测量学、遗传学、蛋白质组学和甲基组学等多种方法。原本不会被使用的组织样本支持了有价值的神经科学研究。
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