Front Cover: Chemical Constituents from Aerial Parts of Baccharis sphenophylla and Effects against Intracellular Forms of Trypanosoma cruzi (Chem. Biodiversity 10/2021),Chemistry & Biodiversity

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Front Cover: Chemical Constituents from Aerial Parts of Baccharis sphenophylla and Effects against Intracellular Forms of Trypanosoma cruzi (Chem. Biodiversity 10/2021)
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2021-09-16 , DOI: 10.1002/cbdv.202100695
Matheus L. Silva ₁ , Thais A. Costa‐Silva ₁ , Guilherme M. Antar ₂ , Andre G. Tempone ₃ , João Henrique G. Lago ₁

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Front Cover. The chromatographic fractionation of the hexane extract from Baccharis sphenophylla afforded the isolation of seven compounds including the unreported 7α-hydroxy-ent-abieta-8(14),13(15)-dien-16,12β-olide (1) and the phenylpropanoid derivative hexacosyl p-coumarate (7). Screening for bioactivity against intracellular amastigotes of the parasite Trypanosoma cruzi revealed compounds 1 and 7 as 10-fold more active to the parasite in relation to mammalian cells, indicating that such compounds could be used as prototypes for the development of new drugs against Chagas disease as reported by M. L. Silva et al. in their full paper at 10.1002/cbdv.202100466.

中文翻译：

封面：来自 Baccharis sphenophylla 空中部分的化学成分和对克氏锥虫细胞内形式的影响（化学生物多样性 10/2021）

封面。从己烷提取物的色谱分离Baccharis sphenophylla得到的7个的化合物的隔离包括未报告7α羟基ENT -abieta-8（14），13（15） -二烯16,12β内酯（1）和苯丙衍生物六糖基对香豆酸酯 ( 7 )。筛选针对寄生虫克氏锥虫的细胞内无鞭毛体的生物活性显示，化合物1和7对哺乳动物细胞的寄生虫活性高 10 倍，表明此类化合物可用作开发针对南美锥虫病的新药的原型，如报告人ML 席尔瓦等。在 10.1002/cbdv.202100466 的全文中。

更新日期：2021-10-19

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