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Smart Tumor-Cell-Derived Microparticles Provide On-Demand Photosensitizer Synthesis and Hypoxia Relief for Photodynamic Therapy
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-09-16 , DOI: 10.1002/anie.202109258
Liping Zuo 1 , Weidong Nie 2 , Songmao Yu 3 , Wanru Zhuang 1 , Guanghao Wu 2 , Houli Liu 1 , Lili Huang 4 , Danshu Shi 5 , Xin Sui 3 , Yongheng Li 3 , Hai-Yan Xie 1
Affiliation  

Accurate co-localization of PpIX and O2: HAL and 3BP-loaded microparticles specifically target and recognize tumor cells, wherein HAL induces the biosynthesis of PpIX in mitochondria and 3BP reduces the mitochondria oxygen consumption. The precise co-localization of PpIX and O2 produces sufficient singlet oxygen to directly disrupt mitochondria, significantly improving PDT.
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中文翻译:

智能肿瘤细胞衍生微粒为光动力疗法提供按需光敏剂合成和缺氧缓解

PpIX 和 O 2 的准确共定位:HAL 和 3BP 负载微粒特异性靶向和识别肿瘤细胞,其中 HAL 诱导线粒体中 PpIX 的生物合成,3BP 降低线粒体耗氧量。PpIX 和 O 2的精确共定位产生足够的单线态氧直接破坏线粒体,显着改善 PDT。
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更新日期:2021-11-15
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