Emerging nanomaterials applied for tackling the COVID-19 cytokine storm,Journal of Materials Chemistry B

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Emerging nanomaterials applied for tackling the COVID-19 cytokine storm
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2021-09-16 , DOI: 10.1039/d1tb01446c
Xi Yang ₁ , Jia You ₂ , Yuanfeng Wei ₁ , Huawei Li ₂ , Ling Gao ₁ , Qing Guo ₃ , Ying Huang ₄ , Changyang Gong ₁ , Cheng Yi ₁

Affiliation

During the global outbreak of coronavirus disease 2019 (COVID-19), a hyperinflammatory state called the cytokine storm was recognized as a major contributor to multiple organ failure and mortality. However, to date, the diagnosis and treatment of the cytokine storm remain major challenges for the clinical prognosis of COVID-19. In this review, we outline various nanomaterial-based strategies for preventing the COVID-19 cytokine storm. We highlight the contribution of nanomaterials to directly inhibit cytokine release. We then discuss how nanomaterials can be used to deliver anti-inflammatory drugs to calm the cytokine storm. Nanomaterials also play crucial roles in diagnostics. Nanomaterial-based biosensors with improved sensitivity and specificity can be used to detect cytokines. In summary, emerging nanomaterials offer platforms and tools for the detection and treatment of the COVID-19 cytokine storm and future pandemic.

中文翻译：

用于应对 COVID-19 细胞因子风暴的新兴纳米材料

在 2019 年冠状病毒病 (COVID-19) 全球爆发期间，称为细胞因子风暴的高炎症状态被认为是导致多器官衰竭和死亡的主要原因。然而，迄今为止，细胞因子风暴的诊断和治疗仍然是 COVID-19 临床预后的主要挑战。在这篇综述中，我们概述了各种基于纳米材料的预防 COVID-19 细胞因子风暴的策略。我们强调了纳米材料对直接抑制细胞因子释放的贡献。然后我们讨论如何使用纳米材料来提供抗炎药物来平息细胞因子风暴。纳米材料在诊断中也起着至关重要的作用。具有更高灵敏度和特异性的基于纳米材料的生物传感器可用于检测细胞因子。总之，

更新日期：2021-09-16

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