Emerging investigator series: examination of the gastrointestinal lipidome of largemouth bass exposed to dietary single-walled carbon nanotubes,Environmental Science: Nano

当前位置： X-MOL 学术 › Environ. Sci.: Nano › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Emerging investigator series: examination of the gastrointestinal lipidome of largemouth bass exposed to dietary single-walled carbon nanotubes
Environmental Science: Nano ( IF 5.8 ) Pub Date : 2021-08-05 , DOI: 10.1039/d1en00303h
Alexis M. Wormington _{1,

2} , Sarah E. Robinson _{1,

2} , David Gabrielli _{1,

2} , Mohammad-Zaman Nouri ₂ , Eric S. Coker ₁ , Nancy D. Denslow _{2,

3} , Tara Sabo-Attwood _{1,

2} , Joseph H. Bisesi _{1,

2}

Affiliation

Carbon nanomaterials are emerging contaminants released into the environment primarily through anthropogenic processes, where they primarily partition into soils and sediments. Aquatic animals that inhabit, forage, or choose prey in the benthic zone are vulnerable to dietary exposure to sediment-associated carbon nanomaterials. Since carbon nanomaterials are hydrophobic, dietary exposure may alter the availability, metabolism, storage, and transport of lipids in the intestinal lumen or at the epithelial barrier, affecting downstream biological processes. To assess the effect of single-walled carbon nanotubes (SWCNTs) on the gastrointestinal lipidome of aquatic species, a feeding experiment with adult largemouth bass (Micropterus salmoides) was conducted. After 8 weeks of exposure to SWCNTs via the diet, the intestinal abundance of ceramides and several classes of lyso- and phospholipids was significantly altered. Additionally, functional profiling with MetaboAnalyst revealed changes in pathways related to fatty acid biosynthesis in exposed fish. These results suggest that though SWCNTs do not pass through the gastrointestinal epithelium, they may alter gut homeostasis through interactions with intestinal lipids.

中文翻译：

新兴研究者系列：检查暴露于膳食单壁碳纳米管的大口黑鲈胃肠脂质组

碳纳米材料是新出现的污染物，主要通过人为过程释放到环境中，它们主要分配到土壤和沉积物中。在底栖区栖息、觅食或选择猎物的水生动物很容易接触到与沉积物相关的碳纳米材料。由于碳纳米材料是疏水性的，饮食暴露可能会改变肠腔或上皮屏障中脂质的可用性、代谢、储存和运输，从而影响下游的生物过程。为了评估单壁碳纳米管 (SWCNT) 对水生物种胃肠道脂质组的影响，进行了成年大口黑鲈 ( Micropterus salmoides )的饲养实验。8周暴露于单壁碳纳米管后，通过饮食、神经酰胺和几类溶血和磷脂的肠道丰度显着改变。此外，使用 MetaboAnalyst 进行的功能分析揭示了与暴露鱼中脂肪酸生物合成相关的途径发生了变化。这些结果表明，虽然单壁碳纳米管不通过胃肠上皮，但它们可能通过与肠道脂质的相互作用改变肠道稳态。

更新日期：2021-09-16

点击分享查看原文

点击收藏

阅读更多本刊最新论文