Iminyl-radicals by electrochemical decarboxylation of α-imino-oxy acids: construction of indole-fused polycyclics,Chemical Communications

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Iminyl-radicals by electrochemical decarboxylation of α-imino-oxy acids: construction of indole-fused polycyclics
Chemical Communications ( IF 4.3 ) Pub Date : 2021-09-08 , DOI: 10.1039/d1cc03891e
Jin-Lin Wan ₁ , Jian-Feng Cui ₁ , Wei-Qiang Zhong ₁ , Jing-Mei Huang ₁

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Iminyl radicals are reactive intermediates that can be used for the construction of various valuable heterocycles. Herein, the electrochemical decarboxylation of α-imino-oxy acids for the generation of iminyl radicals has been accomplished under exogenous-oxidant- and metal-free conditions through the use of nBu₄NBr as a mediator. The resulting iminyl radicals undergo intramolecular cyclization smoothly with the adjacent (hetero)arenes to afford a series of indole-fused polycyclic compounds.

中文翻译：

α-亚氨基羟基酸电化学脱羧的亚胺基：吲哚稠合多环化合物的构建

亚胺基是反应性中间体，可用于构建各种有价值的杂环。在此，通过使用n Bu ₄ NBr 作为介体，在无外源氧化剂和无金属条件下完成了用于产生亚胺基自由基的 α-亚氨基-羟基酸的电化学脱羧。所得亚胺基自由基与相邻的（杂）芳烃顺利进行分子内环化，得到一系列吲哚稠合的多环化合物。

更新日期：2021-09-16

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