Self-adjuvanting photosensitizer nanoparticles for combination photodynamic immunotherapy,Biomaterials Science

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Self-adjuvanting photosensitizer nanoparticles for combination photodynamic immunotherapy
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-08-27 , DOI: 10.1039/d1bm01139a
Guiqiang Zhang ₁ , Ning Wang ₁ , Haifeng Sun ₁ , Xiao Fu ₁ , Shumei Zhai ₁ , Jiwei Cui _{1,

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Affiliation

Combination cancer immunotherapy that synergizes the advantages of multiple therapeutic agents has shown great potential in tumor treatment. Herein, we report the one-step assembly of therapeutic nanoparticles (NPs) to co-deliver photosensitizers and adjuvants for combination photodynamic therapy (PDT) and immunotherapy. The NPs are obtained via self-assembly of chlorin e6 (Ce6) and imidazoquinoline-based TLR7 agonists (IMDQ), which results in a high loading efficacy of 72.2% and 27.8% for Ce6 and IMDQ, respectively. Upon laser irradiation, the resulting NPs could not only effectively induce photodynamic immunogenic cancer cell death, but also elicit robust antitumor immunity, leading to significant inhibition of both primary and distant tumors in a bilateral tumor model. This study demonstrates the potential of self-assembled NPs in co-delivering multiple therapeutics for potential immunotherapy to enhance the antitumor efficacy.

中文翻译：

用于联合光动力免疫治疗的自辅助光敏剂纳米颗粒

协同多种治疗药物优势的联合癌症免疫治疗在肿瘤治疗中显示出巨大的潜力。在此，我们报告了治疗性纳米粒子 (NPs) 的一步组装，以共同递送光敏剂和佐剂，用于联合光动力疗法 (PDT) 和免疫疗法。NPs 是通过二氢卟酚 e6 (Ce6) 和基于咪唑并喹啉的 TLR7 激动剂 (IMDQ) 的自组装，导致 Ce6 和 IMDQ 的加载效率分别为 72.2% 和 27.8%。在激光照射下，所得纳米颗粒不仅可以有效诱导光动力免疫原性癌细胞死亡，还可以引发强大的抗肿瘤免疫，从而显着抑制双侧肿瘤模型中的原发性和远处肿瘤。这项研究证明了自组装 NPs 在共同提供多种疗法以用于潜在的免疫疗法以增强抗肿瘤功效的潜力。

更新日期：2021-09-16

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