A facile method for high-throughput screening of drug-eluting coatings in droplet microarrays based on ultrasonic spray deposition,Biomaterials Science

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A facile method for high-throughput screening of drug-eluting coatings in droplet microarrays based on ultrasonic spray deposition
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-08-26 , DOI: 10.1039/d1bm01213d
Cong Wang ₁ , Yunfan Xue ₁ , Junjie Huang ₁ , Kefeng Ren ₁ , A Greiner ₂ , S Agarwal ₂ , Jian Ji ₁

Affiliation

Coating modification such as drug-eluting coating is one of the most important approaches for the functionalization of biomedical devices. However, the throughputs are limited in conventional coating methods and the concept of miniaturization is rarely fulfilled. A droplet microarray (DMA), as a unique high-throughput platform, can avoid cross-contamination and reduce the consumption of materials which is inherently suitable for coating research yet is difficult to apply with coating materials via traditional methods. Here, we bring up a facile method based on ultrasonic spray deposition to integrate coating materials into a DMA. Several common polymer materials were selected to fabricate a DMA, and the obtained DMA showed the ability to anchor water droplets and form specific patterns. Coating arrays with a typical sandwich structure were also prepared for the high-throughput screening of drug-eluting coatings to demonstrate the potential of the platform in coating research. This developed method is efficient and compatible and enriches the choices of materials that can be applied in DMAs.

中文翻译：

基于超声喷雾沉积的液滴微阵列中药物洗脱涂层的高通量筛选简便方法

药物洗脱涂层等涂层改性是生物医学设备功能化的最重要方法之一。然而，在传统的涂层方法中，产量受到限制，并且很少实现小型化的概念。液滴微阵列（DMA）作为一种独特的高通量平台，可以避免交叉污染，减少材料的消耗，本来适合涂层研究，但很难与涂层材料一起应用传统方法。在这里，我们提出了一种基于超声波喷涂沉积的简便方法，将涂层材料集成到 DMA 中。选择了几种常见的聚合物材料来制造 DMA，得到的 DMA 具有锚定水滴和形成特定图案的能力。还制备了具有典型夹层结构的涂层阵列，用于药物洗脱涂层的高通量筛选，以展示该平台在涂层研究中的潜力。这种开发的方法高效且兼容，丰富了可用于 DMA 的材料选择。

更新日期：2021-09-16

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