Polymeric particles that combine pH responsiveness and anisotropic morphology are reported, based on cross-linked 2-(diethylamino)ethyl methacrylate (DEA) coated polystyrene (PS) particles, obtained via a seeded polymerization procedure. DEA coating results in a single cavity within the seed particles, providing a cup-shaped final morphology. Two hydrophilic monomers, 2-(dimethylamino)ethyl methacrylate (DMA) and allylamine (AAm), are also used to further functionalize the particle surfaces. Through controlled monomer ratios, four pitted particles with different chemical compositions are prepared: DEA, DEA/DMA (two different ratios), and DEA/AAm. Monomer composition precisely tunes the resulting particle morphology, with the ability to change from cup shaped to multicavity. The pH-dependent release properties of the pitted particles are investigated using Rhodamine 6G at pH 6.5 and 7.4. Analysis of drug release kinetics with the Korsmeyer-Peppas model shows the drug release mechanism varies depending on the pH as well as the polymer composition. The biocompatibility of particles is assessed via the MTT cell viability assay.

报告了结合 pH 响应性和各向异性形态的聚合物颗粒，基于交联的 2-（二乙基氨基）甲基丙烯酸乙酯 (DEA) 涂覆的聚苯乙烯 (PS) 颗粒，通过种子聚合程序获得。DEA 涂层导致种子颗粒内有一个空腔，提供杯形的最终形态。两种亲水单体，甲基丙烯酸 2-(二甲氨基)乙酯 (DMA) 和烯丙胺 (AAm)，也用于进一步功能化颗粒表面。通过控制单体比例，制备了四种不同化学成分的麻点颗粒：DEA、DEA/DMA（两种不同的比例）和DEA/AAm。单体成分可精确调整所得颗粒形态，能够从杯形变为多腔。在 pH 6.5 和 7.4 下使用罗丹明 6G 研究了凹坑颗粒的 pH 依赖性释放特性。使用 Korsmeyer-Peppas 模型分析药物释放动力学表明药物释放机制随 pH 值和聚合物组成而变化。通过 MTT 细胞活力测定评估颗粒的生物相容性。