A new coumarin derivative, 7-O-methylparamicoumarin A (1), has been isolated from the roots of Chionanthus retusus, together with seven known compounds. The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, luteolin (3), quercetin (4), and apigenin (5) exhibited cytotoxicities with IC₅₀ values of 13.69 ± 1.10, 10.41 ± 0.79, and 12.25 ± 0.91 μM, respectively, against DLD-1 cell line. Luteolin (3), quercetin (4), and apigenin (5) also exhibited cytotoxicities with IC₅₀ values of 15.35 ± 1.24, 13.52 ± 0.87, and 19.48 ± 1.26 μM, respectively, against CCRF-CEM cell line. In addition, kaempferol (2), apigenin (5), 3,3′,5,5′,7-pentahydroxyflavanone (6), and oleuropein (8) showed potent inhibition with IC₅₀ values of 24.84 ± 1.95, 27.18 ± 1.82, 25.18 ± 2.07, and 28.14 ± 1.66 μM, respectively, against LPS-induced NO generation.

一种新的香豆素衍生物，7-O-甲基副香豆素 A (1)，已从Chionanthus retusus的根中分离出来，以及七种已知的化合物。通过光谱和质谱分析确定了新化合物 1 的结构。在分离株中，木犀草素 (3)、槲皮素 (4) 和芹菜素 (5)对 DLD-1 细胞系表现出细胞毒性，IC ₅₀值分别为 13.69 ± 1.10、10.41 ± 0.79 和 12.25 ± 0.91 μM。木犀草素 (3)、槲皮素 (4) 和芹菜素 (5) 还表现出细胞毒性，对 CCRF-CEM 细胞系的IC ₅₀值分别为 15.35 ± 1.24、13.52 ± 0.87 和 19.48 ± 1.26 μM。此外，山奈酚 (2)、芹菜素 (5)、3,3',5,5',7-五羟基黄烷酮 (6) 和橄榄苦苷 (8) 显示出有效的 IC 抑制作用_{50 个}值分别为 24.84 ± 1.95、27.18 ± 1.82、25.18 ± 2.07 和 28.14 ± 1.66 μM，分别对抗 LPS 诱导的 NO 生成。