当前位置: X-MOL 学术Hepatol. Int. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Non-alcoholic fatty liver disease frequency and associated factors at admission of acute stroke
Hepatology International ( IF 5.9 ) Pub Date : 2021-09-15 , DOI: 10.1007/s12072-021-10253-z
Takahisa Mori 1 , Kazuhiro Yoshioka 1 , Yuhei Tanno 1
Affiliation  

Background/purpose of the study

If non-alcoholic fatty liver disease (NAFLD) frequency is very high in stroke patients, NAFLD may be a risk factor for stroke and identifying factors of NAFLD presence may lead to stroke prevention. This retrospective study aimed to investigate whether NAFLD frequency was very high and identify factors associated with NAFLD presence at acute stroke admission.

Methods

We included stroke patients aged 40 − 79 years who (1) were admitted from 2016 to 2019, within 24 h of onset; (2) underwent abdominal ultrasonography; and (3) underwent blood examination of biomarkers. We evaluated the frequency and significant factors of NAFLD presence.

Results

Among 1672 stroke patients, 676 patients met our inclusion criteria, and 267 patients (39.5%) had NAFLD. Compared to patients without NAFLD, patients with NAFLD were young; had high anthropometric values; high blood pressure; low aspartate aminotransferase/alanine aminotransferase ratio (AST/ALT) ratio; high levels of liver enzymes, serum albumin, HbA1c, and serum lipids; low-density lipoprotein; high serum level of some fatty acids; and high fatty acid% of palmitic acid (PA) and dihomo-gamma-linolenic acid (DGLA). After excluding variables with multicollinearity, independent NAFLD-presence factors were high body mass index (BMI), low AST/ALT ratio, high serum albumin level, high PA%, and high DGLA level.

Conclusions

The frequency of NAFLD was high in our patient group. Significant NAFLD-presence factors were high BMI, low AST/ALT ratio, high serum albumin level, high PA%, and high DGLA level. A further study is warranted to determine the effects of the NAFLD-presence factors on stroke onset or prevention.



中文翻译:

急性卒中入院时非酒精性脂肪肝发病率及相关因素

研究背景/目的

如果中风患者的非酒精性脂肪性肝病 (NAFLD) 频率非常高,则 NAFLD 可能是中风的危险因素,识别 NAFLD 存在的因素可能会导致中风的预防。这项回顾性研究旨在调查 NAFLD 频率是否非常高,并确定与急性卒中入院时 NAFLD 存在相关的因素。

方法

我们纳入了 40-79 岁的卒中患者,他们 (1) 于 2016 年至 2019 年在发病后 24 小时内入院;(2) 进行腹部超声检查;(3) 接受血液生物标志物检查。我们评估了 NAFLD 存在的频率和重要因素。

结果

在 1672 名卒中患者中,676 名患者符合我们的纳入标准,267 名患者(39.5%)患有 NAFLD。与非 NAFLD 患者相比,NAFLD 患者年轻;具有较高的人体测量值;高血压; 低天冬氨酸氨基转移酶/丙氨酸氨基转移酶比率 (AST/ALT) 比率;高水平的肝酶、血清白蛋白、HbA1c 和血脂;低密度脂蛋白; 一些脂肪酸的高血清水平; 和高脂肪酸百分比的棕榈酸 (PA) 和二高-γ-亚麻酸 (DGLA)。排除多重共线性变量后,NAFLD 存在的独立因素是高体重指数 (BMI)、低 AST/ALT 比值、高血清白蛋白水平、高 PA% 和高 DGLA 水平。

结论

在我们的患者组中,NAFLD 的发生率很高。显着的 NAFLD 存在因素是高 BMI、低 AST/ALT 比值、高血清白蛋白水平、高 PA% 和高 DGLA 水平。需要进一步研究以确定 NAFLD 存在因素对中风发作或预防的影响。

更新日期:2021-09-16
down
wechat
bug