Objectives Acute pancreatitis is a rare condition that can be associated with significant complications. The objective of this study is to evaluate the maternal and newborn outcomes associated with acute pancreatitis in pregnancy. Methods A retrospective cohort study using the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample from the United States was performed. All pregnant patients with acute pancreatitis were identified using International Classification of Disease-9 coding from 1999 to 2015. The effect of acute pancreatitis on maternal and neonatal outcomes in pregnancy was evaluated using multivariate logistic regression, while adjusting for baseline maternal characteristics. Results From 1999 to 2015, there were a total of 13,815,919 women who gave birth. There were a total of 14,258 admissions of women diagnosed with acute pancreatitis, including 1,756 who delivered during their admission and 12,502 women who were admitted in the antepartum period and did not deliver during the same admission. Acute pancreatitis was associated with increased risk of prematurity, OR 3.78 (95% CI 3.38–4.22), preeclampsia, 3.81(3.33–4.36), postpartum hemorrhage, 1.90(1.55–2.33), maternal death, 9.15(6.05–13.85), and fetal demise, 2.60(1.86–3.62) among women diagnosed with acute pancreatitis. Among women with acute pancreatitis, delivery was associated with increased risk of requiring transfusions, 6.06(4.87–7.54), developing venous thromboembolisms, 2.77(1.83–4.18), acute respiratory failure, 3.66(2.73–4.91), and disseminated intravascular coagulation, 8.12(4.12–16.03). Conclusions Acute pancreatitis in pregnancy is associated with severe complications, such as maternal and fetal death. Understanding the risk factors that may lead to these complications can help prevent or minimize them through close fetal and maternal monitoring.

中文翻译：

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妊娠合并急性胰腺炎的围产期结局

目的 急性胰腺炎是一种罕见的疾病，可能与严重的并发症有关。本研究的目的是评估与妊娠期急性胰腺炎相关的母婴结局。方法使用来自美国的医疗保健成本和利用项目-全国住院患者样本进行回顾性队列研究。使用国际疾病分类 9 编码从 1999 年到 2015 年确定所有患有急性胰腺炎的妊娠患者。使用多变量逻辑回归评估急性胰腺炎对妊娠期母婴结局的影响，同时调整基线母体特征。结果1999年至2015年，共有13815919名妇女生育。一共有14个，258 名被诊断患有急性胰腺炎的女性入院，其中 1,756 名在入院期间分娩，12,502 名在产前入院但在同一入院期间未分娩的女性。急性胰腺炎与早产风险增加相关，OR 3.78（95% CI 3.38-4.22），先兆子痫，3.81（3.33-4.36），产后出血，1.90（1.55-2.33），孕产妇死亡，9.15（6.05-13.85），和胎儿死亡，2.60（1.86-3.62）在诊断为急性胰腺炎的妇女中。在患有急性胰腺炎的女性中，分娩与需要输血的风险增加有关，6.06（4.87-7.54），发生静脉血栓栓塞，2.77（1.83-4.18），急性呼吸衰竭，3.66（2.73-4.91）和弥散性血管内凝血， 8.12（4.12-16.03）。结论 妊娠期急性胰腺炎与严重并发症相关，如母婴死亡。了解可能导致这些并发症的风险因素有助于通过密切的胎儿和母体监测来预防或减少这些并发症。