Objectives Obstructive sleep apnea (OSA) is linked to many health comorbidities. We aimed to ascertain if OSA correlates with a rise in poor obstetrical outcomes. Methods Employing the United States’ Healthcare Cost and Utilization Project – National Inpatient Sample, we performed our retrospective cohort study including all women who delivered between 2006 and 2015. ICD-9 codes were used to characterize women as having a diagnosis of OSA. Temporal trends in pregnancies with OSA were studied, baseline features were evaluated among gravidities in the presence and absence of OSA, and multivariate logistic regression analysis was utilized in assessing consequences of OSA on patient and newborn outcomes. Results Of a total 7,907,139 deliveries, 3,115 belonged to patients suffering from OSA, resulting in a prevalence of 39 per 100,000 deliveries. Rates rose from 10.14 to 78.12 per 100,000 deliveries during the study interval (p<0.0001). Patients diagnosed with OSA were at higher risk of having pregnancies with preeclampsia, OR 2.2 (95% CI 2.0–2.4), eclampsia, 4.1 (2.4–7.0), chorioamnionitis, 1.4 (1.2–1.8), postpartum hemorrhage, 1.4 (1.2–1.7), venous thromboembolisms, 2.7 (2.1–3.4), and to deliver by caesarean section, 2.1 (1.9–2.3). Cardiovascular and respiratory complications were also more common among these women, as was maternal death, 4.2 (2.2–8.0). Newborns of OSA patients were at elevated risk of being premature, 1.3 (1.2–1.5) and having congenital abnormalities, 2.3 (1.7–3.0). Conclusions Pregnancies with OSA were linked to an elevated risk of poor maternal and neonatal outcomes. During pregnancy, OSA patients should receive attentive follow-up care in a tertiary hospital.

中文翻译：

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阻塞性睡眠呼吸暂停妊娠的母婴结局

目标 阻塞性睡眠呼吸暂停 (OSA) 与许多健康合并症有关。我们旨在确定 OSA 是否与不良产科结果的增加相关。方法 采用美国的医疗保健成本和利用项目 - 全国住院患者样本，我们进行了回顾性队列研究，包括 2006 年至 2015 年期间分娩的所有女性。ICD-9 代码用于将女性描述为诊断为 OSA。研究了 OSA 妊娠的时间趋势，评估了存在和不存在 OSA 的妊娠的基线特征，并利用多变量逻辑回归分析评估 OSA 对患者和新生儿结局的影响。结果 在总共 7,907,139 例分娩中，有 3,115 例属于 OSA 患者，每 100,000 例分娩中有 39 例患病率。在研究期间，每 100,000 次分娩的发生率从 10.14 上升到 78.12（p<0.0001）。诊断为 OSA 的患者发生先兆子痫的风险较高，OR 2.2 (95% CI 2.0–2.4)，子痫，4.1 (2.4–7.0)，绒毛膜羊膜炎，1.4 (1.2–1.8)，产后出血，1.4 (1.2– 1.7)，静脉血栓栓塞，2.7 (2.1–3.4)，剖宫产，2.1 (1.9–2.3)。这些女性的心血管和呼吸系统并发症也更常见，孕产妇死亡率为 4.2 (2.2-8.0)。OSA 患者的新生儿早产风险升高，1.3 (1.2-1.5) 和先天性异常，2.3 (1.7-3.0)。结论 OSA 妊娠与孕产妇和新生儿不良结局风险升高有关。在怀孕期间，OSA 患者应在三级医院接受细心的随访护理。