Urinary tract infections (UTI) are one of the most common diseases worldwide and Escherichia coli is the most common causative bacteria. Empirical treatment is challenging due to antimicrobial or multidrug-resistance. The aims of this study were to determine the uropathogens and their antimicrobial susceptibility profile, as well as to identify the phylogroups and virulence genes of E. coli strains, associated with community-acquired UTI in outpatients admitted at a Brazilian Hospital in southeast Brazil. In total, 47 bacterial strains were isolated from 47 patients, 44 women and 2 men (no gender record from one patient). The age of the patients whose urine culture were positive varied from 0 (less than one month) to 104 years. Most of the isolates were E. coli (41/47), followed by Klebsiella pneumoniae (2/47), Klebsiella variicola/Klebsiella aerogenes (1/47), Pseudomonas aeruginosa (1/47), Proteus mirabilis (1/47), and Citrobacter koseri (1/47). Most E. coli strains were classified as phylogroup B2 (15/41 = 36.59%) and B1 (12/41 = 29.27%) and the most common virulence genes among E. coli strains were fimH (31/41 = 75.61%), iutA (21/41 = 51.22%), and tratT (16/41 = 39.02%). Among the E. coli strains, 59% were multidrug-resistance and strains that were ampicillin, sulfamethoxazole/trimethoprim, or tetracycline-resistant exhibited more chance to be multidrug-resistance, with an odds ratio of 100.00 [95% confidence interval (CI) 9.44–1059.26], 22.50 (95% CI 3.95–128.30), and 12.83 (95% CI 2.68–61.45), respectively. Our results showed that E. coli was the main etiological agent identified and demonstrated high frequency of multidrug-resistance and virulence factors in bacterial strains isolated from UTIs.

尿路感染 (UTI) 是世界范围内最常见的疾病之一，大肠杆菌是最常见的致病菌。由于抗菌素或多药耐药性，经验性治疗具有挑战性。本研究的目的是确定尿路病原体及其抗菌药敏感性特征，并确定与社区获得性 UTI 相关的大肠杆菌菌株的系统群和毒力基因，这些菌株与在巴西东南部巴西医院住院的门诊患者中的社区获得性 UTI 相关。总共从 47 名患者中分离出 47 株细菌，其中 44 名女性和 2 名男性（一名患者没有性别记录）。尿培养阳性患者的年龄从0（不到1个月）到104岁不等。大多数分离株是大肠杆菌(41/47)，其次是肺炎克雷伯菌(2/47)、天花克雷伯菌/产气克雷伯菌(1/47)、铜绿假单胞菌(1/47)、奇异变形杆菌(1/47) 和科氏柠檬酸杆菌(1/47) ）。大多数大肠杆菌菌株被分类为系统群 B2 (15/41 = 36.59%) 和 B1 (12/41 = 29.27%)，大肠杆菌菌株中最常见的毒力基因为fimH (31/41 = 75.61%)，iutA (21/41 = 51.22%) 和tratT (16/41 = 39.02%)。在大肠杆菌中在菌株中，59% 为多药耐药，氨苄青霉素、磺胺甲恶唑/甲氧苄氨嘧啶或四环素耐药菌株表现出更多的多药耐药几率，优势比为 100.00 [95% 置信区间 (CI) 9.44–1059.26]，分别为 22.50（95% CI 3.95-128.30）和 12.83（95% CI 2.68-61.45）。我们的研究结果表明，大肠杆菌是主要的病原体，并且在从 UTI 中分离的细菌菌株中表现出高频率的多药耐药性和毒力因子。