Collision breast tumors, consisting of breast cancer (BC) and non-Hodgkin’s lymphoma (NHL), are extremely rare. Here we report the case of a 64-year-old woman with a collision tumor in her left breast mass that was composed of invasive ductal carcinoma and small lymphocytic lymphoma/chronic lymphocytic leukemia. In addition, we reviewed the published comparable English-language literature. Collision breast tumor composed of BC and NHL is extremely rare. For that reason, there is a lack of consensus about the underlying mechanism, and diagnosing it without delay remains a complex clinical challenge. We found that post-menopausal, age-related estrogen levels changes and Epstein-Barr virus infection are possible pathogenic factors. However, the symptoms are almost identical, and it is difficult to distinguish a simple breast tumor from a breast collision tumor. In this study, we reviewed the clinical features of all patients with BC and NHL colliding breast tumors; this information might enable early identification and prevention of misdiagnosis.

中文翻译：

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浸润性导管癌和小淋巴细胞淋巴瘤/慢性淋巴细胞白血病表现为碰撞性乳腺肿瘤：1例报告并文献复习

由乳腺癌 (BC) 和非霍奇金淋巴瘤 (NHL) 组成的碰撞性乳腺肿瘤极为罕见。在这里，我们报告了一名 64 岁女性的病例，她的左乳房肿块有一个碰撞肿瘤，由浸润性导管癌和小淋巴细胞淋巴瘤/慢性淋巴细胞白血病组成。此外，我们回顾了已发表的可比较的英语文献。由BC和NHL组成的碰撞性乳腺肿瘤极为罕见。出于这个原因，对潜在机制缺乏共识，并且毫不拖延地对其进行诊断仍然是一项复杂的临床挑战。我们发现绝经后、年龄相关的雌激素水平变化和 Epstein-Barr 病毒感染是可能的致病因素。但是，症状几乎相同，单纯的乳腺肿瘤和乳腺碰撞肿瘤很难区分。在这项研究中，我们回顾了所有 BC 和 NHL 碰撞性乳腺肿瘤患者的临床特征；这些信息可能有助于及早识别和预防误诊。