During an epidemic or pandemic, the primary task is to rapidly develop precise diagnostic approaches and effective therapeutics. Oligonucleotide aptamer-based pathogen detection assays and control therapeutics are promising, as aptamers that specifically recognize and block pathogens can be quickly developed and produced through simple chemical synthesis. This work reviews common aptamer-based diagnostic techniques for communicable diseases and summarizes currently available aptamers that target various pathogens, including the SARS-CoV-2 virus. Moreover, this review discusses how oligonucleotide aptamers might be leveraged to control pathogen propagation and improve host immune system responses. This review offers a comprehensive data source to the further develop aptamer-based diagnostics and therapeutics specific for infectious diseases.

中文翻译：

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用于病原体检测和传染病控制的寡核苷酸适体。

在流行病或大流行期间，首要任务是快速开发精确的诊断方法和有效的治疗方法。基于寡核苷酸适体的病原体检测分析和控制疗法很有前景，因为可以通过简单的化学合成快速开发和生产特异性识别和阻断病原体的适体。这项工作回顾了常见的基于适配体的传染病诊断技术，并总结了目前针对各种病原体（包括 SARS-CoV-2 病毒）的可用适配体。此外，这篇综述讨论了如何利用寡核苷酸适体来控制病原体繁殖和改善宿主免疫系统反应。该综述为进一步开发针对传染病的基于适体的诊断和治疗方法提供了全面的数据源。