Tissue regeneration following injury from disease or medical treatment still represents a challenge in regeneration medicine. Prostaglandin E2 (PGE2), which involves diverse physiological processes via E-type prostanoid (EP) receptor family, favors the regeneration of various organ systems following injury for its capabilities such as activation of endogenous stem cells, immune regulation, and angiogenesis. Understanding how PGE2 modulates tissue regeneration and then exploring how to elevate the regenerative efficiency of PGE2 will provide key insights into the tissue repair and regeneration processes by PGE2. In this review, we summarized the application of PGE2 to guide the regeneration of different tissues, including skin, heart, liver, kidney, intestine, bone, skeletal muscle, and hematopoietic stem cell regeneration. Moreover, we introduced PGE2-based therapeutic strategies to accelerate the recovery of impaired tissue or organs, including 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitors boosting endogenous PGE2 levels and biomaterial scaffolds to control PGE2 release.

中文翻译：

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前列腺素 E2 在组织修复和再生中的作用。

疾病或医疗损伤后的组织再生仍然是再生医学的挑战。前列腺素 E2 (PGE2) 通过 E 型前列腺素 (EP) 受体家族参与多种生理过程，因其具有激活内源性干细胞、免疫调节和血管生成等功能，有利于损伤后各种器官系统的再生。了解 PGE2 如何调节组织再生，然后探索如何提高 PGE2 的再生效率，将为 PGE2 的组织修复和再生过程提供重要见解。在这篇综述中，我们总结了 PGE2 在指导不同组织再生中的应用，包括皮肤、心脏、肝脏、肾脏、肠道、骨骼、骨骼肌和造血干细胞的再生。而且，