Sox transcription factors play many diverse roles during development, including regulating stem cell states, directing differentiation, and influencing the local chromatin landscape. Sox10 has been implicated in the control of stem/progenitor activity and epithelial-mesenchymal transition, yet it has not been studied in relation to the hair follicle cycle or hair follicle stem cell (HFSC) control. To elucidate the role of Sox10 in hair follicle cycle control, we performed immunohistochemical and immunofluorescence analysis of its expression during hair morphogenesis, the postnatal hair cycle, and the depilation-induced murine hair follicle cycle. During hair follicle morphogenesis, Sox10 was expressed in the hair germ and peg. In telogen, we detected nuclear Sox10 in the hair bulge and germ cell cap, where HFSCs reside, while in anagen and catagen, Sox10 was detected in the epithelial portion, such as the strands of keratinocytes, the outer root sheath (ORS) in anagen, and the regressed epithelial strand of hair follicle in catagen. These results suggest that Sox10 may be involved in early hair follicle morphogenesis and postnatal follicular cycling.

中文翻译：

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Sox10 在毛囊形态发生和诱导毛发周期过程中的表达和定位。

Sox 转录因子在发育过程中发挥着许多不同的作用，包括调节干细胞状态、指导分化和影响局部染色质景观。Sox10 与控制干细胞/祖细胞活性和上皮间质转化有关，但尚未对其与毛囊周期或毛囊干细胞 (HFSC) 控制相关的研究。为了阐明 Sox10 在毛囊周期控制中的作用，我们对其在毛发形态发生、出生后毛发周期和脱毛诱导的小鼠毛囊周期中的表达进行了免疫组织化学和免疫荧光分析。在毛囊形态发生过程中，Sox10 在毛胚和 peg 中表达。在休止期，我们在 HFSC 所在的毛发隆起和生殖细胞帽中检测到核 Sox10，而在生长期和退行期，在上皮部分检测到 Sox10，如角质形成细胞链、生长期外根鞘 (ORS) 和退行期毛囊退化的上皮链。这些结果表明，Sox10 可能参与早期毛囊形态发生和出生后毛囊循环。