In view of efficiency, simple operation, and affordable cost and disposability, quartz tuning fork systems form good candidates for mechanical-based biosensors in point of care applications. Based on the geometrical structure, the frequency response of the tuning fork- based sensors is dependent on the location of absorbed samples. In order to have the maximum efficiency and sensitivity, the optimized condition of sample loading on the fork structures should be considered. In this regard, here, we have determined the optimized sample location to be on the prongs of the quartz tuning fork by calculating the frequency response of the quartz tuning fork using the finite element method. From an application point of view, we have obtained an agreement between the calculational method and the experimental excitation technique of the structure. The results from our study show that by using an appropriate location for the sample, the quartz tuning fork could be exploited with high sensitivity.

考虑到效率、操作简单、成本低廉和可处置性，石英音叉系统是护理应用中基于机械的生物传感器的良好候选者。基于几何结构，基于音叉的传感器的频率响应取决于吸收样本的位置。为了获得最大的效率和灵敏度，应考虑叉结构上样品加载的优化条件。就此而言，在这里，我们通过使用有限元方法计算石英音叉的频率响应，确定了优化的样本位置在石英音叉的叉齿上。从应用的角度来看，我们获得了该结构的计算方法和实验激励技术的一致性。我们的研究结果表明，通过使用适当的样品位置，可以以高灵敏度利用石英音叉。