PURPOSE The present study evaluated changes in bone tracer uptake (BTU) after medial open-wedge high tibial osteotomy (MOWHTO) and determined whether postoperative BTU correlates with clinical symptoms, radiologic parameters, or cartilage regeneration following MOWHTO. METHODS A total of 210 knees underwent MOWHTO for medial compartmental osteoarthritis (OA) were enrolled in this study. Mean follow-up period was 42.7 months. We assessed BTU for the medial compartment of the knee before MOWHTO and at the time of plate removal. Radiologic parameters included Kellgren-Lawrence (K-L) grade and Hip-Knee-Ankle angle (HKAA). Clinical evaluation included American Knee Society (AKS) score and cartilage status was graded at the time of MOWHTO and second-look arthroscopy according to the International Cartilage Repair Society (ICRS) grading system and articular cartilage regeneration stage. Statistical analysis performed to assess the relationships among postoperative BTU of the medial compartment, radiologic parameters, arthroscopic changes and clinical outcomes. RESULTS BTU of medial femoral condyle and tibial plateau were significantly decreased at 2 years after MOWHTO (p<0.001). AKS scores and arthroscopic cartilage status were also significantly improved following MOWHTO. BMI and postoperative HKAA showed significant correlations with postoperative changes of BTU in uni- and multi-variable analysis. Meanwhile, postoperative changes of BTU did not show significant correlation with clinical outcomes or cartilage regeneration following MOWHTO. CONCLUSION Lower BMI and postoperative valgus alignment were significant predictor for postoperative BTU decrease of the medial compartment following MOWHTO. However, postoperative changes of BTU did not reflect cartilage regeneration or clinical outcomes until the midterm follow-up.

中文翻译：

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术后定量骨显像是否反映了内侧开放楔形胫骨高位截骨术后的结果？

目的本研究评估了内侧开放楔形胫骨高位截骨术 (MOWHTO) 后骨示踪剂摄取 (BTU) 的变化，并确定术后 BTU 是否与 MOWHTO 后的临床症状、放射学参数或软骨再生相关。方法 共有 210 名膝关节因内侧间室骨关节炎 (OA) 接受 MOWHTO 治疗。平均随访时间为 42.7 个月。我们在 MOWHTO 之前和移除钢板时评估了膝关节内侧隔室的 BTU。放射学参数包括 Kellgren-Lawrence (KL) 等级和髋膝踝角 (HKAA)。临床评估包括美国膝关节协会 (AKS) 评分和根据国际软骨修复协会 (ICRS) 分级系统和关节软骨再生阶段在 MOWHTO 和二次关节镜检查时对软骨状态进行分级。进行统计分析以评估内侧隔室的术后 BTU、放射学参数、关节镜变化和临床结果之间的关系。结果 MOWHTO 术后 2 年，股骨内侧髁和胫骨平台的 BTU 显着降低（p<0.001）。MOWHTO 后 AKS 评分和关节镜软骨状态也显着改善。在单变量和多变量分析中，BMI和术后HKAA与术后BTU变化显着相关。同时，术后 BTU 的变化与 MOWHTO 后的临床结果或软骨再生没有显着相关性。结论 较低的 BMI 和术后外翻对齐是 MOWHTO 后内侧隔室术后 BTU 降低的重要预测因素。然而，直到中期随访，BTU 的术后变化并不能反映软骨再生或临床结果。